骨关节炎软骨下骨的微结构改变

被引:25
作者
叶臻 [1 ]
李民 [2 ]
陈定家 [1 ]
机构
[1] 漳州市中医院骨科
[2] 福建中医药大学附属康复医院骨科
关键词
骨关节炎; 软骨下骨; 微损伤; 骨髓水肿样病变; 骨囊肿;
D O I
暂无
中图分类号
R684.3 [关节炎];
学科分类号
100220 [骨科学];
摘要
骨关节炎(OA)是老年人中常见疾病,在过去几十年中,软骨下骨组织结构的改变被认为在OA病因中起重要参与作用,软骨下骨微结构损伤将导致其加重。OA病理进程中可以在软骨下骨检测到一些微结构改变,包括微损伤,骨髓水肿样病变和骨囊肿等。关节软骨下骨的微结构改变与骨关节炎进展高度相关,软骨下骨微结构损伤将导致骨关节炎的加重保持软骨下骨的完整性可作为防治骨关节炎的方法之一。了解OA软骨下骨的微结构改变,阐明骨关节炎软骨下骨微结构损伤的发生机理及其与骨关节炎发生发展间关系,将有助于OA的诊断、预防和治疗。
引用
收藏
页码:624 / 627
页数:4
相关论文
共 21 条
[1]
Subchondral insufficiency fractures of the knee: review of imaging findings [J].
Jose, Jean ;
Pasquotti, Giulio ;
Smith, Marvin K. ;
Gupta, Akhil ;
Lesniak, Bryson P. ;
Kaplan, Lee D. .
ACTA RADIOLOGICA, 2015, 56 (06) :714-719
[2]
Interspecies Comparison of Subchondral Bone Properties Important for Cartilage Repair [J].
Chevrier, Anik ;
Kouao, Ahou S. M. ;
Picard, Genevieve ;
Hurtig, Mark B. ;
Buschmann, Michael D. .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2015, 33 (01) :63-70
[3]
MRI of subchondral fractures: a review [J].
Viana, Sergio Lopes ;
Machado, Bruno Beber ;
Mendlovitz, Paulo Sergio .
SKELETAL RADIOLOGY, 2014, 43 (11) :1515-1527
[4]
Three-dimensional analysis of subchondral cysts in hip osteoarthritis: An ex vivo HR-pQCT study.[J].Ko Chiba;Andrew J. Burghardt;Makoto Osaki;Sharmila Majumdar.Bone.2014,
[5]
Bone–cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies.[J].X.L. Yuan;H.Y. Meng;Y.C. Wang;J. Peng;Q.Y. Guo;A.Y. Wang;S.B. Lu.Osteoarthritis and Cartilage.2014, 8
[6]
The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study [J].
Crema, M. D. ;
Cibere, J. ;
Sayre, E. C. ;
Roemer, F. W. ;
Wong, H. ;
Thorne, A. ;
Singer, J. ;
Esdaile, J. M. ;
Marra, M. D. ;
Kopec, J. A. ;
Nicolaou, S. ;
Guermazi, A. .
OSTEOARTHRITIS AND CARTILAGE, 2014, 22 (04) :540-546
[7]
Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees [J].
Kazakia, G. J. ;
Kuo, D. ;
Schooler, J. ;
Siddiqui, S. ;
Shanbhag, S. ;
Bernstein, G. ;
Horvai, A. ;
Majumdar, S. ;
Ries, M. ;
Li, X. .
OSTEOARTHRITIS AND CARTILAGE, 2013, 21 (01) :94-101
[8]
Subchondral bone and osteoarthritis: biological and cellular aspects.[J].Y. Henrotin;L. Pesesse;C. Sanchez.Osteoporosis International.2012, 8
[9]
Temporal and spatial migration pattern of the subchondral bone plate in a rabbit osteochondral defect model [J].
Orth, P. ;
Cucchiarini, M. ;
Kaul, G. ;
Ong, M. F. ;
Graeber, S. ;
Kohn, D. M. ;
Madry, H. .
OSTEOARTHRITIS AND CARTILAGE, 2012, 20 (10) :1161-1169
[10]
Magnetic Resonance Imaging of Subchondral Bone Marrow Lesions in Association with Osteoarthritis [J].
Xu, Li ;
Hayashi, Daichi ;
Roemer, Frank W. ;
Felson, David T. ;
Guermazi, Ali .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2012, 42 (02) :105-118