急性脑梗死患者阿司匹林抵抗危险因素分析

被引：23

作者：

邓琳 ^{[1
]}

邱丽君 ^{[1
]}

顾青 ^{[1
]}

王根发 ^{[2
]}

机构：

[1] 上海交通大学医学院附属新华医院检验科

[2] 上海交通大学医学院附属新华医院老年医学科

来源：

检验医学 | 2013年 / 28卷 / 09期

关键词：

脑梗死; 阿司匹林抵抗; 血栓弹力图;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的探讨急性脑梗死患者阿司匹林抵抗(AR)现象及其影响因素。方法收集330例急性脑梗死患者,根据血栓弹力图测定花生四烯酸(AA)诱导途径的血小板抑制率。血小板抑制率≤20%即判定为AR,抑制率在20%～50%之间则判定为阿司匹林半抵抗(ASR),抑制率>50%即为阿司匹林敏感(AS)。根据上述标准将患者进行分组,研究AR的发生率,并分析各组间各项临床特征的差异,采用Logistic回归分析影响AR与ASR的危险因素。结果 330例急性脑梗死患者中AR发生率为33.9%,ASR发生率为19.7%。与AS组相比,AR+ASR组中高敏C反应蛋白(hs-CRP)水平明显升高(P<0.05)。≥65岁患者中,高风险患者AR+ASR发生率显著升高(P<0.05)。Logistic回归分析表明血小板计数[OR=0.996,95%可信区间(CI):0.991～0.999,P=0.041]和hs-CRP(OR=0.972,95%CI:0.959～0.996,P=0.014)是发生AR与ASR的危险因素。结论急性脑梗死患者AR的发生率较可能与血小板数量和患者炎症状态有关。

引用

页码：765 / 769

页数：5

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