多囊卵巢综合征患者合并代谢综合征的患病率和预测指标

被引:110
作者
武红琴 [1 ]
阮祥燕 [1 ,2 ]
卢永军 [1 ]
田玄玄 [1 ]
张颖 [1 ]
崔亚美 [1 ]
赵越 [1 ]
杜娟 [1 ]
李扬璐 [1 ]
Diethelm Wallwiener [2 ]
Alfred OMueck [1 ,2 ]
机构
[1] 首都医科大学附属北京妇产医院内分泌科
[2] 德国图宾根大学妇产医院内分泌与绝经中心
关键词
多囊卵巢综合征; 代谢综合征; 患病率; 预测指标;
D O I
暂无
中图分类号
R711.75 [卵巢疾病]; R589 [代谢病];
学科分类号
100201 [内科学]; 100211 [妇产科学];
摘要
目的探讨多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者代谢综合征(metabolic syndrome,MS)及其各组分的发病情况,评估MS各组分对预测PCOS患者合并MS的预测能力。方法选取2013年12月至2014年7月就诊于首都医科大学附属北京妇产医院内分泌科被确诊为多囊卵巢综合征患者180例,所有患者均收集人体测量学指标、基础内分泌指标和血糖血脂等生物化学指标,评估PCOS患者MS及其各组分的发病情况,筛选对PCOS患者发生MS高风险的预测指标。结果 1 180例PCOS患者MS的患病率为43.89%;2不同年龄段的患病率分别为17~24岁32.14%、25~29岁39.53%、30~34岁50%、35~39岁80%;正常体质量、超质量、肥胖、重度肥胖的患病率非别为10.00%、51.16%、69.57%、85.71%;3合并有MS的PCOS患者的年龄和体质量指数均高于非MS的PCOS患者(29.16±3.85 vs 27.47±3.81,P=0.004;31.44±4.89 vs 24.29±4.87,P=0.000),两组患者的血总睾酮浓度差异无统计学意义(P<0.05);4 PCOS患者发生MS最好的预测指标是高密度脂蛋白胆固醇<1.29 mmol/L(敏感度为91.14%,特异度为88.12%)。结论 PCOS患者是发生代谢综合征的高风险人群,年龄和肥胖情况是决定不同人群代谢综合征患病率的关键因素。通过高密度脂蛋白胆固醇水平可以较好的评估PCOS患者发生代谢综合征的风险。
引用
收藏
页码:553 / 558
页数:6
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