尼可地尔对经皮冠状动脉介入治疗心肌损伤的影响

被引：6

作者：

李妍慧

依力米努尔

机构：

[1] 新疆维吾尔自治区人民医院北院心内科

来源：

中国循证心血管医学杂志 | 2012年 / 4卷 / 05期

关键词：

尼可地尔; 经皮冠状动脉介入治疗; 心肌保护;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的观察经皮冠状动脉介入治疗(PCI)术前服用尼可地尔对心肌损伤的影响。方法纳入行择期PCI治疗的冠心病患者100例,随机分为尼可地尔组(n=52)和常规治疗组(n=48)。常规治疗组接受冠心病及PCI术常规药物治疗,尼可地尔组在PCI术前接受7天口服尼可地尔(5mg,tid)治疗,并在PCI术前5h加服尼可地尔5mg。比较两组患者PCI术前及术后6h、18h、24h的肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)水平的变化。结果两组患者在PCI术前cTnI和CK-MB水平无差异(P>0.05);PCI术后6h、18h、24h,尼可地尔组cTnI和CK-MB水平均低于常规治疗组,差异均有统计学意义(P<0.05)。结论冠心病患者择期PCI术前使用尼可地尔,对PCI术造成的心肌损伤有一定保护作用。

引用

页码：460 / 461

页数：2

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