N-甲基-D-天冬氨酸受体与抑郁症相关性研究进展

被引:9
作者
梁余槟 [1 ]
徐运 [2 ]
机构
[1] 南京中医药大学中西医结合鼓楼临床医学院神经内科
[2] 南京中医药大学第一临床医学院鼓楼医院神经科
关键词
D O I
10.19845/j.cnki.zfysjjbzz.2015.04.032
中图分类号
R749.4 [情感性精神病];
学科分类号
100204 [神经病学];
摘要
<正>抑郁症是常见的心理精神障碍,是一种以明显而持久的心境低落为主要特征的临床综合征。随着社会生活节奏的加快,压力的剧增,抑郁症已经成为临床上常见病、高发病,且其发病率呈上升趋势[1]。《世界卫生组织2002年度报告》中指出,按目前发病增长的速度,到2020年抑郁症可能成为仅次于心脏病的致残性疾病[2],然而,当前近乎一半的抗抑郁药物疗效欠佳,所以重新认识抑郁症的发病机制对抗抑郁新药的研发十分必要。抑郁症的确切发病机制尚不完全清
引用
收藏
页码:383 / 384
页数:2
相关论文
共 11 条
[1]
抑郁症治疗研究新进展 [J].
瞿伟 ;
谷珊珊 .
第三军医大学学报, 2014, 36 (11) :1113-1117
[2]
抑郁症的治疗研究进展 [J].
刘佳莉 ;
苑玉和 ;
陈乃宏 .
中国药理学通报 , 2011, (09) :1193-1196
[3]
Neural circuits underlying the pathophysiology of mood disorders.[J].Joseph L. Price;Wayne C. Drevets.Trends in Cognitive Sciences.2011, 1
[4]
Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test [J].
Zomkowski, Andrea D. E. ;
Engel, Daiane ;
Gabilan, Nelson H. ;
Rodrigues, Ana Lucia S. .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2010, 20 (11) :793-801
[5]
Glial and glutamatergic markers in depression; alcoholism; and their comorbidity.[J].José Javier Miguel-Hidalgo;Robert Waltzer;Angela A. Whittom;Mark C. Austin;Grazyna Rajkowska;Craig A. Stockmeier.Journal of Affective Disorders.2010, 1
[6]
Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression [J].
Price, Rebecca B. ;
Nock, Matthew K. ;
Charney, Dennis S. ;
Mathew, Sanjay J. .
BIOLOGICAL PSYCHIATRY, 2009, 66 (05) :522-526
[7]
Increased levels of glutamate in brains from patients with mood disorders [J].
Hashimoto, Kenji ;
Sawa, Akira ;
Iyo, Masaomi .
BIOLOGICAL PSYCHIATRY, 2007, 62 (11) :1310-1316
[8]
Correlation between plasma levels of glutamate, alanine and serine with severity of depression [J].
Mitani, Hideaki ;
Shirayama, Yukihiko ;
Yamada, Takeshi ;
Maeda, Kazuhisa ;
Ashby, Charles R., Jr. ;
Kawahara, Ryuzou .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2006, 30 (06) :1155-1158
[9]
Controlled trial of d -cycloserine adjuvant therapy for treatment-resistant major depressive disorder.[J].Uriel Heresco-Levy;Daniel C. Javitt;Yovgenia Gelfin;Elena Gorelik;Marina Bar;Monica Blanaru;Ilana Kremer.Journal of Affective Disorders.2006, 1
[10]
A double-blind, cross-over comparison of the effects of amantadine or placebo-on visuomotor and cognitive function in medicated schizophrenia patients [J].
Silver, H ;
Goodman, C ;
Isakov, V ;
Knoll, G ;
Modai, I .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2005, 20 (06) :319-326