缺氧微环境在肿瘤进展中的作用

被引：87

作者：

秦承东 ^{[1
]}

任正刚 ^{[1
,2
]}

汤钊猷 ^{[1
]}

机构：

[1] 复旦大学附属中山医院肝癌研究所,教育部癌变与侵袭重点实验室

[2] 复旦大学附属中山医院肝内科

来源：

肿瘤 | 2016年 / 01期

关键词：

肿瘤; 缺氧; 肿瘤微环境; 肿瘤转移; 肿瘤干细胞;

D O I：

暂无

中图分类号：

R730.231 [肿瘤病因学、发生学];

学科分类号：

100214 [肿瘤学];

摘要：

缺氧微环境是实体肿瘤的重要特征。在缺氧条件下,肿瘤细胞会分泌多种血管生长因子以促进异常血管的形成。同时为了寻找更佳适宜的土壤,肿瘤细胞的侵袭与转移能力也会得到进一步的提高。此外,缺氧微环境对肿瘤细胞具有筛选作用,使肿瘤的恶性程度进一步提高,导致肿瘤细胞对化疗药物或放射治疗不敏感。由此可见,缺氧微环境是肿瘤的不良预后的重要因素。相较于肿瘤组织,正常组织中很少存在缺氧区域,所以缺氧微环境也为肿瘤的靶向治疗提供了有利条件。本文就缺氧微环境的成因、与肿瘤的相互关系和干预策略等进行综述,以期为靶向肿瘤缺氧微环境的治疗提供一些理论依据。

引用

页码：96 / 102

页数：7

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