兔股动脉粥样硬化症改良模型的建立及其评价

被引：10

作者：

黄成磊 ^{[1
]}

李天奇 ^{[1
]}

乔伟伟 ^{[2
]}

罗心平 ^{[1
]}

李剑 ^{[1
]}

倪唤春 ^{[1
]}

沈伟 ^{[1
]}

李宏治 ^{[3
]}

金波 ^{[1
]}

施海明 ^{[1
]}

机构：

[1] 复旦大学附属华山医院心内科

[2] 复旦大学实验动物科学部

[3] 复旦大学附属金山医院ICU

来源：

实验动物与比较医学 | 2007年 / 01期

关键词：

动脉粥样硬化; 新西兰兔; 动物模型; 球囊扩张;

D O I：

暂无

中图分类号：

R-332 [医用实验动物学];

学科分类号：

摘要：

目的建立新西兰兔股动脉粥样硬化改良模型,探讨其可行性并与传统造模方法进行比较。方法西兰兔通过高脂饲料饲养后,在X线透视下经颈动脉行股动脉球囊损伤,建立改良动脉粥样硬化模型。与传统造模方法相比,评判造模前后的冠状动脉造影血流分级(Thrombolysis in Myocardial Infarction,TIMI)评分、管腔内径,血管内膜厚度和泡沫细胞阳性面积的变化,以及血凝血酶原时间(Prothrombin Time,PT)值的变化。结果与对照组比较,改良模型组的股动脉管腔内径显著狭窄(P<0.001),其狭窄程度与动脉内膜增厚程度存在相关性(r=-0.753)。同时,血管内膜泡沫细胞阳性面积率显著增多(P=0.018)。该变化与传统造模组相比,更为显著。结论改良法建立粥样斑块模型不但具有可行性,而且可控程度高、易重复。这种造模方法可以通过微创技术TIMI评分与血液生化学进行评价;与传统模型相比,更有助于进一步阐明不稳定斑块的机制。

引用

页码：6 / 10

页数：5

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