胃癌基因诊断和治疗的研究进展

被引:16
作者
沈志勇
刘骅
曹晖
机构
[1] 上海交通大学医学院附属仁济医院普外科
关键词
胃癌; 基因诊断; 基因治疗; DNA甲基化; 错配修复基因; 癌基因;
D O I
暂无
中图分类号
R735.2 [胃肿瘤];
学科分类号
100112 [医学生物化学与分子生物学];
摘要
目的回顾胃癌基因诊断和治疗的研究进展。方法复习相关资料,就近年来胃癌基因诊断和治疗方面的研究进展作一综述。结果使用基因技术检测肿瘤标志物对胃癌的早期发现、预后监测、疗效判断等都具有较大的临床意义。胃癌的基因治疗还有许多问题需进一步解决。结论基因检测及治疗将成为胃癌诊治的重要辅助手段。
引用
收藏
页码:500 / 502
页数:3
相关论文
共 18 条
[1]
Molecular targets and biological modifiers in gastric cancer [J].
Carneiro, Fatima ;
Oliveira, Carla ;
Leite, Marina ;
Seruca, Raquel .
SEMINARS IN DIAGNOSTIC PATHOLOGY, 2008, 25 (04) :274-287
[2]
Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1 [J].
Guo, CC ;
Ding, J ;
Yao, LP ;
Sun, L ;
Lin, T ;
Song, Y ;
Sun, LJ ;
Fan, DM .
INTERNATIONAL JOURNAL OF CANCER, 2005, 116 (01) :155-160
[3]
CD80 gene therapy for lymph node involvement by gastric carcinoma [J].
Kosaka, K ;
Yashiro, M ;
Sakate, Y ;
Tanaka, H ;
Sunami, T ;
Ohira, M ;
Hirakawa, K .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2004, 25 (05) :1319-1325
[4]
Exogenous wild-type p16INK4A gene induces delayed cell proliferation and promotes chemosensitivity through decreased pRB and increased E2F-1 expressions [J].
Jeong, YW ;
Kim, KS ;
Oh, JY ;
Park, JC ;
Baek, WK ;
Suh, SI ;
Suh, MH ;
Lee, JC ;
Cho, JW .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2003, 12 (01) :61-65
[5]
The molecular basis and potential role of survivin in cancer diagnosis and therapy [J].
Altieri, DC .
TRENDS IN MOLECULAR MEDICINE, 2001, 7 (12) :542-547
[6]
Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues [J].
Leung, WK ;
Yu, J ;
Ng, EKW ;
To, KF ;
Ma, PK ;
Lee, TL ;
Go, MYY ;
Chung, SCS ;
Sung, JJY .
CANCER, 2001, 91 (12) :2294-2301
[7]
Functional interleukin-4 receptor and interleukin-2 receptor common gamma chain in human gastric carcinoma: A possible mechanism for cytokine-based therapy [J].
Essner, R ;
Huynh, Y ;
Nguyen, T ;
Rose, DM ;
Kojima, M ;
Hoon, DSB .
JOURNAL OF GASTROINTESTINAL SURGERY, 2001, 5 (01) :81-90
[8]
Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment [J].
Yoshida, T ;
Mizuno, M ;
Taniguchi, K ;
Nakayashiki, N ;
Wakabayashi, T ;
Yoshida, J .
JOURNAL OF SURGICAL ONCOLOGY, 2001, 76 (01) :19-25
[9]
BIOTECHNOLOGICAL AND GENE THERAPEUTIC STRATEGIES IN CANCER-TREATMENT [J].
WELS, W ;
MORITZ, D ;
SCHMIDT, M ;
JESCHKE, M ;
HYNES, NE ;
GRONER, B .
GENE, 1995, 159 (01) :73-80
[10]
纳米炭吸附5-FU淋巴靶向化疗对胃癌组织及转移淋巴结bcl-2、bax及caspase-3表达的影响 [J].
黄斌 ;
李昂 ;
张波 ;
程中 ;
陈志新 ;
陈佳平 .
中国普外基础与临床杂志, 2009, 16 (01) :18-22