人乳头瘤病毒及其致瘤机制的研究进展

被引：16

作者：

梁德光

何之恒

蓝柯

机构：

[1] 中国科学院上海巴斯德研究所

来源：

生命科学 | 2008年 / 20卷 / 06期

关键词：

人乳头瘤病毒; 致瘤; 宫颈癌;

D O I：

暂无

中图分类号：

R737.33 [子宫肿瘤];

学科分类号：

100214 ;

摘要：

高危型人乳头瘤病毒(human papilloma virus,HPV)的持续感染是导致妇女宫颈癌发生的一个关键因素。HPV感染宫颈上皮细胞后,可以通过抑制免疫应答,在部分个体中建立潜伏感染。高危HPV编码的蛋白在持续感染的过程中,操控了细胞多种重要功能,如凋亡、增殖、细胞周期调控等,使得宫颈上皮细胞的形态学、遗传物质、表观遗传学等都发生重要改变。部分感染人群的宫颈上皮细胞因此会被转化,并在协同因子相互作用下,逐渐转化为宫颈癌。HPV在宫颈癌发生过程中起着重要的作用,本文将对HPV感染致宫颈癌机制最近的研究进展进行综述。

引用

页码：843 / 848

页数：6

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