晚期结直肠癌的化疗进展

被引:40
作者
李文桦
张文
机构
[1] 复旦大学附属肿瘤医院肿瘤内科复旦大学上海医学院肿瘤学系
关键词
结直肠癌; 化疗; 转移;
D O I
暂无
中图分类号
R735.34 [];
学科分类号
摘要
化疗是晚期结直肠癌的主要治疗手段,以氟尿嘧啶(5-fluorouracil,5-FU)、奥沙利铂和伊立替康为主的三药是晚期肠癌治疗的重要药物,联合化疗和"打打停停"的治疗模式在提高疗效的同时兼顾了治疗的耐受性。新的化疗药物雷替曲塞、替吉奥和TAS-102也在临床中获得应用。就晚期结直肠癌化疗的进展进行综述。
引用
收藏
页码:877 / 889
页数:13
相关论文
共 16 条
[1]
中国人尿苷二磷酸葡糖苷酸转移酶1A基因多态性与伊立替康毒性的相关性.[J].王岩;徐建明;沈琳;徐农;王金万;焦顺昌;张京生;宋三泰;李健;包悍英;杨林;李方;.中华肿瘤杂志.2007, 12
[2]
The SOFT trial: a Phase III study of the dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine S-1 and oxaliplatin (SOX) plus bevacizumab as first-line chemotherapy for metastatic colorectal cancer [J].
Nakamura, Masato ;
Yamada, Yasuhide ;
Muro, Kei ;
Takahashi, Keiichi ;
Baba, Hideo ;
Sasaki, Yasutsuna ;
Komatsu, Yoshito ;
Satoh, Taroh ;
Mishima, Hideyuki ;
Watanabe, Masahiko ;
Sakata, Yuh ;
Morita, Satoshi ;
Shimada, Yasuhiro ;
Sugihara, Kenichi .
FUTURE ONCOLOGY, 2015, 11 (10) :1471-1478
[3]
UGT1A1*6 polymorphisms are correlated with irinotecan-induced toxicity: a system review and meta-analysis in Asians [J].
Cheng, Lei ;
Li, Ming ;
Hu, Jing ;
Ren, Wei ;
Xie, Li ;
Sun, Zhan-Peng ;
Liu, Bao-Rui ;
Xu, Gen-Xing ;
Dong, Xiao-Liang ;
Qian, Xiao-Ping .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 73 (03) :551-560
[4]
Capecitabine Plus Irinotecan Versus 5-FU/Leucovorin Plus Irinotecan in the Treatment of Colorectal Cancer: A Meta-analysis [J].
Guo, Yuanbiao ;
Shi, Min ;
Shen, Xiaoheng ;
Yang, Chen ;
Yang, Liu ;
Zhang, Jun .
CLINICAL COLORECTAL CANCER, 2014, 13 (02) :110-118
[5]
TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial [J].
Yoshino, Takayuki ;
Mizunuma, Nobuyuki ;
Yamazaki, Kentaro ;
Nishina, Tomohiro ;
Komatsu, Yoshito ;
Baba, Hideo ;
Tsuji, Akihito ;
Yamaguchi, Kensei ;
Muro, Kei ;
Sugimoto, Naotoshi ;
Tsuji, Yasushi ;
Moriwaki, Toshikazu ;
Esaki, Taito ;
Hamada, Chikuma ;
Tanase, Takanori ;
Ohtsu, Atsushi .
LANCET ONCOLOGY, 2012, 13 (10) :993-1001
[6]
Efficacy and safety of bevacizumab-based combination regimens in patients with previously untreated metastatic colorectal cancer: Final results from a randomised phase ii study of bevacizumab plus 5-fluorouracil; leucovorin plus irinotecan versus bevacizumab plus capecitabine plus irinotecan (FNCLCC ACCORD 13/0503 study).[J]..European Journal of Cancer.2012,
[7]
Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer [J].
Komatsu, Yoshito ;
Yuki, Satoshi ;
Sogabe, Susumu ;
Fukushima, Hiraku ;
Nakatsumi, Hiroshi ;
Kobayashi, Yoshimitsu ;
Iwanaga, Ichiro ;
Nakamura, Michio ;
Hatanaka, Kazuteru ;
Miyagishima, Takuto ;
Kudo, Mineo ;
Munakata, Masaki ;
Meguro, Takashi ;
Tateyama, Miki ;
Sakata, Yuh .
ACTA ONCOLOGICA, 2012, 51 (07) :867-872
[8]
Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000–05): an open-label; randomised; phase 3 trial.[J].Michel Ducreux;David Malka;Jean Mendiboure;Pierre-Luc Etienne;Patrick Texereau;Dominique Auby;Philippe Rougier;Mohamed Gasmi;Marine Castaing;Moncef Abbas;Pierre Michel;Dany Gargot;Ahmed Azzedine;Catherine Lombard-Bohas;Patrick Geoffroy;Bernard Denis;Jean-Pierre Pignon;Laurent Bedenne;Olivier Bouché.Lancet Oncology.2011, 11
[9]
Capecitabine plus oxaliplatin (XELOX) versus 5‐fluorouracil/leucovorin plus oxaliplatin (FOLFOX‐6) as first‐line treatment for metastatic colorectal cancer.[J].MichelDucreux;JaafarBennouna;MohamedHebbar;MarcYchou;GérardLledo;ThierryConroy;AntoineAdenis;RogerFaroux;ChristineRebischung;LoicBergougnoux;LeilaKockler;Jean‐YvesDouillard.Int. J. Cancer.2010, 3
[10]
Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study) [J].
Muro, Kei ;
Boku, Narikazu ;
Shimada, Yasuhiro ;
Tsuji, Akihito ;
Sameshima, Shinichi ;
Baba, Hideo ;
Satoh, Taroh ;
Denda, Tadamichi ;
Ina, Kenji ;
Nishina, Tomohiro ;
Yamaguchi, Kensei ;
Takiuchi, Hiroya ;
Esaki, Taito ;
Tokunaga, Shinya ;
Kuwano, Hiroyuki ;
Komatsu, Yoshito ;
Watanabe, Masahiko ;
Hyodo, Ichinosuke ;
Morita, Satoshi ;
Sugihara, Kenichi .
LANCET ONCOLOGY, 2010, 11 (09) :853-860