磷酸二酯酶7:一个新的抗炎免疫药物靶点研究进展

Stereoelectronic properties of spiroquinazolinones in differential PDE7 inhibitory activity[J] Pankaj R.Daga;Robert J.Doerksen J. Comput. Chem. 2008,

Purification of recombinant human phosphodiesterase 7A expressed in Dictyostelium discoideum[J] Ranjana Arya;Shivani Gupta;Saima Aslam;Namrata Jit Kaur;Aayush Seth;Mathew S. Eapen;Renu Malik;Lalitha Vijayakrishnan;Kulvinder Singh Saini Protein Expression and Purification 2008,

Small-molecule inhibitors of PDE-IV and -VII in the treatment of respiratory diseases and chronic inflammation[J] Vijayakrishnan;Rudra;Eapen;Dastidar;Ray Expert Opinion on Investigational Drugs 2007,

Cloning; stable expression of human phosphodiesterase 7A and development of an assay for screening of PDE7 selective inhibitors[J] Renu Malik;Roop Singh Bora;Dikshi Gupta;Pratibha Sharma;Ranjana Arya;Shiwani Chaudhary;Kulvinder Singh Saini Applied Microbiology and Biotechnology 2008,

The effects of a novel phosphodiesterase 7A and -4 dual inhibitor; YM-393059; on T-cell-related cytokine production in vitro and in vivo[J] Satoshi Yamamoto;Shingo Sugahara;Ryo Naito;Atsushi Ichikawa;Ken Ikeda;Toshimitsu Yamada;Yasuaki Shimizu European Journal of Pharmacology 2006,

Phosphodiesterase 7A1 is expressed in human CD4+ na?ve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation[J] Arsenio Nueda;Nuria García-Roger;Teresa Domenech;Nuria Godessart;Alvaro Cárdenas;Luis F. Santamaría-Babi;Jorge Beleta Cellular Immunology 2006,

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure–activity relationships[J] James Kempson;William J. Pitts;Joseph Barbosa;Junqing Guo;Omonike Omotoso;Andrew Watson;Karen Stebbins;Gary C. Starling;John H. Dodd;Joel C. Barrish;Raymond Felix;Karl Fischer Bioorganic & Medicinal Chemistry Letters 2005,

Neuronal expression of cAMP-specific phosphodiesterase 7B mRNA in the rat brain[J] E. Reyes-Irisarri;S. Pérez-Torres;G. Mengod Neuroscience 2005,

Identification of purine inhibitors of phosphodiesterase 7 (PDE7)[J] William J. Pitts;Wayne Vaccaro;Tram Huynh;Katerina Leftheris;Jacques Y. Roberge;Joseph Barbosa;Junqing Guo;Baerbel Brown;Andrew Watson;Karen Donaldson;Gary C. Starling;Peter A. Kiener;Michael A. Poss;John H. Dodd;Joel C. Barrish Bioorganic & Medicinal Chemistry Letters 2004,

Stereoelectronic properties of spiroquinazolinones in differential PDE7 inhibitory activity[J] Pankaj R.Daga;Robert J.Doerksen J. Comput. Chem. 2008,

Purification of recombinant human phosphodiesterase 7A expressed in Dictyostelium discoideum[J] Ranjana Arya;Shivani Gupta;Saima Aslam;Namrata Jit Kaur;Aayush Seth;Mathew S. Eapen;Renu Malik;Lalitha Vijayakrishnan;Kulvinder Singh Saini Protein Expression and Purification 2008,

Small-molecule inhibitors of PDE-IV and -VII in the treatment of respiratory diseases and chronic inflammation[J] Vijayakrishnan;Rudra;Eapen;Dastidar;Ray Expert Opinion on Investigational Drugs 2007,

Cloning; stable expression of human phosphodiesterase 7A and development of an assay for screening of PDE7 selective inhibitors[J] Renu Malik;Roop Singh Bora;Dikshi Gupta;Pratibha Sharma;Ranjana Arya;Shiwani Chaudhary;Kulvinder Singh Saini Applied Microbiology and Biotechnology 2008,

The effects of a novel phosphodiesterase 7A and -4 dual inhibitor; YM-393059; on T-cell-related cytokine production in vitro and in vivo[J] Satoshi Yamamoto;Shingo Sugahara;Ryo Naito;Atsushi Ichikawa;Ken Ikeda;Toshimitsu Yamada;Yasuaki Shimizu European Journal of Pharmacology 2006,

Phosphodiesterase 7A1 is expressed in human CD4+ na?ve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation[J] Arsenio Nueda;Nuria García-Roger;Teresa Domenech;Nuria Godessart;Alvaro Cárdenas;Luis F. Santamaría-Babi;Jorge Beleta Cellular Immunology 2006,

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure–activity relationships[J] James Kempson;William J. Pitts;Joseph Barbosa;Junqing Guo;Omonike Omotoso;Andrew Watson;Karen Stebbins;Gary C. Starling;John H. Dodd;Joel C. Barrish;Raymond Felix;Karl Fischer Bioorganic & Medicinal Chemistry Letters 2005,

Neuronal expression of cAMP-specific phosphodiesterase 7B mRNA in the rat brain[J] E. Reyes-Irisarri;S. Pérez-Torres;G. Mengod Neuroscience 2005,

Identification of purine inhibitors of phosphodiesterase 7 (PDE7)[J] William J. Pitts;Wayne Vaccaro;Tram Huynh;Katerina Leftheris;Jacques Y. Roberge;Joseph Barbosa;Junqing Guo;Baerbel Brown;Andrew Watson;Karen Donaldson;Gary C. Starling;Peter A. Kiener;Michael A. Poss;John H. Dodd;Joel C. Barrish Bioorganic & Medicinal Chemistry Letters 2004,