白术多糖对环磷酰胺诱导的免疫抑制小鼠白细胞数量及功能的修复作用

被引：66

作者：

相雪莲 ^{[1
,2
]}

许丹宁 ^{[1
,2
]}

曹楠 ^{[1
,2
]}

钱隆 ^{[1
,2
]}

田允波 ^{[1
,2
]}

李婉雁 ^{[1
,2
]}

机构：

[1] 仲恺农业工程学院动物科技学院

[2] 广东省水禽健康养殖重点实验室

来源：

中国兽医杂志 | 2020年 / 56卷 / 07期

关键词：

白术多糖; 小鼠; 环磷酰胺; 免疫功能; 白细胞;

D O I：

暂无

中图分类号：

S853.74 [中兽医药理学];

学科分类号：

090604 [动物药学];

摘要：

为研究白术多糖对环磷酰胺诱导免疫抑制小鼠白细胞数量和功能的修复作用,本试验灌胃白术多糖溶液[200 mg/(kg·bw)]分别处理正常及环磷酰胺[80 mg/(kg·bw)]诱导的免疫抑制小鼠,计算小鼠白细胞相对数量及比例;观察胸腺、脾脏及股骨骨髓组织结构;检测中性粒细胞吞噬功能、血清中IL-2含量及脾脏中B淋巴细胞分泌抗体能力。结果显示,白术多糖能显著提升免疫抑制小鼠白细胞数量,修复胸腺、脾脏和骨髓组织及细胞的损伤,增强中性粒细胞吞噬能力及T、B淋巴细胞功能(P<0.05),并可明显提高正常小鼠血清IL-2含量及B淋巴细胞分泌抗体量(P<0.05)。表明白术多糖不仅对免疫抑制小鼠的白细胞数量及功能有明显的正向促进作用,还能够显著提高正常小鼠的淋巴细胞功能。

引用

页码：36 / 41+2 +2

页数：7

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