慢性疼痛基因治疗的研究现状与展望

[1] Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat. Garry MG,Malik S,Yu J,et al. NeuroReport . 2000

[2] Decreases in endomorphin-2-like immunoreactivity concomitant with chronic pain after nerve injury. Smith RR,Martin-Schild S,Kastin AJ,et al. Neuroscience . 2001

[3] Human gene therapy. Anderson WF. Nature . 1998

[4] In vivo control of NMDA receptor transcript in motoneurons by viral transduction of a short antisense gene. Finegold AA,Perez FM,Ladarola MJ. Brain Research Molecular Brain Research . 2001

[5] Electoporation for direct spinal gene transfer in rats. Li CR,Tai MH,Cheng JT,et al. Neuroscience Letters . 2002

[6] Spinal expression of mRNA for immediate early genes in a model of chronic pain. Delander GE,Schott E,Brodin E,et al. Acta Physiologica Scandinavica . 1997

[7] Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors. Yu XM,Salter MW. Proceedings of the National Academy of Sciences of the United States of America . 1999

[8] lmplantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance. Wu HH,Wilcox GL,Mcloon SC. The Journal of Neuroscience . 1994

[9] Transplants of neuronal cells bioengineered to synthesize GABA alleviate chronic neuropathic pain. Eaton MJ,Plunkett JA,Martinez MA,et al. Cell Transplantation . 1999

[10] Plasticy of the nervous system at the systematic, cellular and molecular levels: a mechanism of chronic pain and hyperalgesia. Zimmermann M,Herdegen T. Progress in Brain Research . 1996

[1] Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat. Garry MG,Malik S,Yu J,et al. NeuroReport . 2000

[2] Decreases in endomorphin-2-like immunoreactivity concomitant with chronic pain after nerve injury. Smith RR,Martin-Schild S,Kastin AJ,et al. Neuroscience . 2001

[3] Human gene therapy. Anderson WF. Nature . 1998

[4] In vivo control of NMDA receptor transcript in motoneurons by viral transduction of a short antisense gene. Finegold AA,Perez FM,Ladarola MJ. Brain Research Molecular Brain Research . 2001

[5] Electoporation for direct spinal gene transfer in rats. Li CR,Tai MH,Cheng JT,et al. Neuroscience Letters . 2002

[6] Spinal expression of mRNA for immediate early genes in a model of chronic pain. Delander GE,Schott E,Brodin E,et al. Acta Physiologica Scandinavica . 1997

[7] Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors. Yu XM,Salter MW. Proceedings of the National Academy of Sciences of the United States of America . 1999

[8] lmplantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance. Wu HH,Wilcox GL,Mcloon SC. The Journal of Neuroscience . 1994

[9] Transplants of neuronal cells bioengineered to synthesize GABA alleviate chronic neuropathic pain. Eaton MJ,Plunkett JA,Martinez MA,et al. Cell Transplantation . 1999

[10] Plasticy of the nervous system at the systematic, cellular and molecular levels: a mechanism of chronic pain and hyperalgesia. Zimmermann M,Herdegen T. Progress in Brain Research . 1996