炎症相关骨质疏松症的发病机制

被引：50

作者：

夏婷

李双庆

机构：

[1] 四川大学华西医院金卡病房(全科病房)

来源：

中国骨质疏松杂志 | 2015年 / 21卷 / 01期

关键词：

骨质疏松症; 炎症;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

炎症相关骨质疏松症是指炎症特别是系统性炎症引起的骨量减少、骨质破坏。近期的研究发现多种炎性疾病与骨质疏松症相关,炎症引起骨质疏松的发病涉及环氧化酶-2(COX-2)、白细胞介素、肿瘤坏死因子α(TNF-alpha)、RANKL/RANK/OPG系统、C反应蛋白、一氧化氮(nitric oxide)、端粒酶等,发病机制的研究促进了denosumab等骨质疏松新药的研发。

引用

页码：117 / 120

页数：4

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