头孢拉定对黄芩苷大鼠体内药动学的影响

被引：4

作者：

车庆明

陈颖

彭金年

机构：

[1] 北京大学药学院

来源：

中草药 | 2006年 / 10期

关键词：

黄芩苷; 头孢拉定; 药动学; 药物相互作用;

D O I：

暂无

中图分类号：

R285.61 [];

学科分类号：

1008 ;

摘要：

目的研究头孢拉定对黄芩苷在大鼠体内药动学的影响。方法用HPLC-ECD方法测定头孢拉定和黄芩苷合并给药组与黄芩苷单独给药组黄芩苷在大鼠体内的血药浓度,比较两者的药动学参数。结果头孢拉定和黄芩苷合并给药组黄芩苷Cmax为(782.63±469.37)ng/mL,AUC0～24h为(8407.86±3476.14)ng/mL·h;黄芩苷单独给药组黄芩苷Cmax为(2645.62±601.42)ng/mL,AUC0～24h为(28952.90±5731.42)ng/mL·h。结论两者药动学参数存在显著性差异(P<0.05),口服头孢拉定严重降低了黄芩苷的血药浓度。提示临床应合理用药。

引用

页码：1530 / 1532

页数：3

共 7 条

[1]

A puegative action of barbaloin is induced by Eubacterium spStrain BAR,a hu-man intestinal anaerobe,capable of transforming barbaloin to aloe emoin anthron. Akao T,Che Q M,Kobashi K,et al. Biological and Pharmaceutical Bulletin . 1996

[2]

Purification and charac-terization of a novel sennoside-hydrolyzing beta-glucoside from Bifidobacterium spStrain SEN,a human intestinal anaerobe. Yang L,Akao T,Kobashi K,et al. Biological and Pharmaceutical Bulletin . 1996

[3]

Bacterioides J-37,a hu-man intestinal baceterium,producesα-glucuronidase. Kim D H,Jand I S,Lee S W,et al. Bi-ol Pharm Bull . 1997

[4]

Metabolites of baicalin in human urine. Zhou Y J,Chen Q M. Pharmazie . 2000

[5]

Baicalin,the predominant flavone glucuronide of Scutellariae Radix,is ab-sorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. Akao T,Kawabata K,Yanaginsawa E,et al. Journal of Pharmacokinetics and Pharmacodynamics . 2000

[6]

Main ginseng saponin metabolites formed by intestinal bacteria. Hasegawa H,Sung J H,Matsumiya S,et al. Planta Medica . 1996

[7]

Metabolism of paeoni-florin and related compounds by human intestinal bavteria. Shu Y Z,Hattori M,Akao T,et al. Chemical and Pharmaceutical Bulletin . 1987

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