VEGF测定在急性心肌梗死中的意义

被引：4

作者：

陆钫

段俊丽

王一尘

机构：

[1] 上海第二医科大学新华医院老年医学科

[2] 上海第二医科大学新华医院老年医学科上海

[3] 上海

来源：

上海第二医科大学学报 | 2004年 / 06期

关键词：

急性心肌梗死; 血管内皮生长因子; 侧枝循环;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨急性心肌梗死(AMI)患者血清血管内皮生长因子(VEGF)含量的变化及意义。方法观察16例AMI患者经过冠状动脉成型术,以及肝素、硝酸酯类药物、阿斯匹林等治疗前后血清VEGF的变化。于发病第1、3、14d和28d分别测定血清VEGF的含量。结果发病后第1 d血清VEGF的浓度与对照组无显著差别(85±11)vs(72±2)pg/mL(P>0.05)。发病后第3 d,VEGF的浓度较第1 d明显升高(150±46)vs(85±11)pg/mL(P<0.001)。发病后第7 d达高峰(171±31)vs(85±11)pg/mL(P<0.0001)。之后开始下降,但第28 d仍明显高于第1 d(142±132)vs(85±11)pg/mL(P<0.001)。结论AMI治疗后VEGF的水平明显持续增高,可能与缺血心肌的血管新生及冠状血管侧枝循环的建立有关。

引用

页码：466 / 468

页数：3

共 9 条

[1]

Clinical evidence of angiogenesis following arterial gene transfer of phVEGF165. Isner,JM. The Lancet . 1996

[2]

VEGF gene transfer mobilizes endothelial progenitor rells in patients with inoperative coronary disease. Kalka C,Tebrani H,Laudenberg B,et al. The Annals of Thoracic Surgery . 2000

[3]

Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angio genesis. Pearhman,JD,Hibbert MG,Chuang ML,et al. Nature Medicine . 1995

[4]

Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Baumgartner I,Pieczek A,Manor O,et al. Circulation . 1998

[5]

Early expression of angioge nesis factors in acute myocardial ischemia and infarction. Lee SH,Wolf PL,Escudero R,et al. The New England Journal of Medicine . 2000

[6]

Gene therapy for myocar dial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Losordo,DW,Vale PR,Symes JF,et al. Circulation . 1998

[7]

Salvage of in farct myocardium by angiogenic action of basic fibroblast growth fac tor. Yanagisawa-Miwa A,Uchida Y,Nakamura F,et al. Science . 1992

[8]

Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. Isner JM,A Sahara T. The Journal of Clinical Investigation . 1999

[9]

Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Mutin M,Canavy I,Blann A,et al. Blood . 1999

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