蛋白质的聚乙二醇修饰及其在医药研究中的应用附视频

被引:7
作者
郑宝胜
徐明波
姚志建
机构
[1] 军事医学科学院基础医学研究所
[2] 军事医学科学院基础医学研究所 北京
[3] 北京
关键词
聚乙二醇; 化学修饰; 蛋白药物;
D O I
暂无
中图分类号
学科分类号
摘要
生物工程的发展使许多蛋白质类药物的广泛使用成为可能,但仍存在免疫原性、毒副反应等问题.蛋白质的化学修饰从某种程度上克服了上述不足。如消除抗原性、延长体内作用时间等,从而提高了药物蛋白质的效率.文章主要介绍聚乙二醇对蛋白质的修饰及其在抗肿瘤蛋白质、调节代谢酶类、溶血栓因子、抗炎症酶及血浆蛋白研究中的一些进展.
引用
收藏
页码:267 / 270
页数:4
相关论文
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