糖尿病心肌病相关信号通路的研究进展

被引：19

作者：

尹茂山 ^{[1
,2
]}

牟艳玲 ^{[1
,3
]}

机构：

[1] 济南大学-山东省医学科学院医学与生命科学学院

[2] 山东省医学科学院药物研究所

[3] 山东省罕少见病重点实验室

来源：

生命科学 | 2014年 / 26卷 / 10期

关键词：

糖尿病心肌病; 信号通路; 发病机制;

D O I：

10.13376/j.cbls/2014155

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学];

摘要：

糖尿病心肌病是一种独立、特异的心肌病,与糖尿病患者发生心力衰竭和死亡率升高密切相关。高血糖引起的心血管并发症涉及心肌病变和血管病变、心肌细胞结构的改变、信号通路和炎症因子的改变等,导致心肌纤维化、心肌肥厚、心脏肥大、心力衰竭和心律失常。综述了糖尿病心肌病发病机制中研究较多的几条信号通路,探究各信号通路在糖尿病心肌病发生、发展过程中对心脏的保护(损伤)作用的相关研究进展。

引用

页码：1084 / 1089

页数：6

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