外源性LIF和IL-1对围着床期小鼠子宫内膜整合素β3亚基表达的调节

被引：22

作者：

张炜

周剑萍

刘银坤

朱瑾

机构：

[1] 上海医科大学妇产科医院!上海,上海医科大学妇产科医院!上海,上海医科大学中山医院肝癌研究所!上海,上海医科大学妇产科医院!上海

来源：

中国免疫学杂志 | 2001年 / 02期

关键词：

D O I：

暂无

中图分类号：

R321 [人体胚胎学（人体胎生学、发生学）];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

Objective:To study regulation of external leukemia inhibitory factor(LIF) and interlukin 1(IL 1) on the expression of integrin β 3 in the mouse endometrium during peri implantation period and explore the mechanism which LIF participate in embryonic implantation.Methods:The mice were injected peritoneally with LIF,IL 1 or IL 1ra at different administration on day 2～4 of pregnancy.The level of integrin β 3 protein was measured with Westernblot method and mRNA measured with RT PCR.Results:The levels of integrin β 3 protein and mRNA were increased by LIF and IL 1(P<0.05) and which relied on administration.The level of integrin β 3 mRNA was decreased by IL 1ra (P<0.05).Conclusion:LIF and IL 1 of cytokines can improve the expression of integrin β 3 in the peri implantation endometrium of mouse.Both of them may take part in implantation by regulating cell adhesion molecules.

引用

页码：93 / 95

页数：3