JAK/STAT信号通路在动脉粥样硬化中的作用

被引：15

作者：

黄伟彬

吕磊

张岚

机构：

[1] 上海交通大学医学院附属仁济医院血管外科

来源：

上海交通大学学报(医学版) | 2013年 / 33卷 / 04期

关键词：

动脉粥样硬化; JAK/STAT信号通路; 内皮细胞; 平滑肌细胞; 炎症细胞;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

动脉粥样硬化(AS)是一种慢性炎症疾病,包含血管细胞和炎症细胞之间复杂的相互作用。酪氨酸激酶/信号转导子和转录激活子(JAK/STAT)信号通路是多种细胞因子和生长因子在细胞内传递信号的共同途径,参与机体免疫反应、血管细胞迁移增殖和凋亡等多种生物学活动。文章对目前JAK/STAT信号通路在AS发生和发展中的作用进行了综述。

引用

页码：506 / 509

页数：4

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