肿瘤微环境的代谢重编程

被引:7
作者
王可
王芳
余红秀
机构
[1] 复旦大学生物医学研究院
关键词
肿瘤微环境; 免疫细胞; 代谢重编程;
D O I
暂无
中图分类号
R730.3 [肿瘤免疫学与血清学];
学科分类号
100108 [医学免疫学];
摘要
肿瘤细胞独特的有氧糖酵解代谢为其增殖生长提供能量,消耗了肿瘤微环境中的大量营养。肿瘤微环境中也存在大量的免疫细胞,免疫细胞活化、执行效应功能会发生与肿瘤细胞类似的代谢重编程现象,亦需要大量能量。因此免疫细胞与肿瘤细胞之间会存在激烈的代谢竞争,同时也存在密切的代谢调控。通过调整肿瘤代谢和免疫代谢的平衡,人为地抑制肿瘤代谢、增强免疫代谢,提高肿瘤内的免疫功能可能为肿瘤免疫治疗开辟一个新的方向。
引用
收藏
页码:152 / 156
页数:5
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