星点设计-效应面法优化芷芎散温敏凝胶的处方及其鼻黏膜渗透特性研究

被引：15

作者：

卢浩扬

林媛媛

车俊秀

曾维东

陈宝

吴传斌

徐月红

机构：

[1] 中山大学药学院

来源：

中草药 | 2014年 / 45卷 / 13期

基金：

广东省科技计划;

关键词：

白芷; 川芎; 泊洛沙姆; 温敏凝胶; 体外释放; 鼻黏膜渗透性;

D O I：

暂无

中图分类号：

R283.6 [剂型];

学科分类号：

100802 [中药炮制学];

摘要：

目的制备并优化芷芎散鼻用温敏凝胶的处方,并考察其体外释放机制和鼻黏膜渗透特性。方法利用星点设计-效应面法优化泊洛沙姆温敏凝胶基质处方,然后经Franz扩散池法考察欧前胡素、阿魏酸的体外释放机制及其离体家兔鼻黏膜渗透特性。结果最优处方为泊洛沙姆407(P407)20%、泊洛沙姆188(P188)6.5%,欧前胡素接近零级释放模型,阿魏酸接近Higuchi模型,处方对欧前胡素和阿魏酸的透过鼻黏膜均具有促进作用。结论优化所得的处方为芷芎散新给药途径制剂的开发提供基础。

引用

页码：1845 / 1849

页数：5

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