肺泡巨噬细胞对豚鼠气道平滑肌张力的调控

被引:2
作者
秦晓群
孙秀泓
张长青
庄义皋
机构
[1] 湖南医科大学生理学教研室,湖南医科大学生理学教研室,湖南医科大学生理学教研室,湖南医科大学生理学教研室长沙,长沙,长沙,长沙
关键词
气管平滑肌; 肺泡巨噬细胞; 血小板; PGE1; 血小板活化因子;
D O I
10.13459/j.cnki.cjap.1991.03.006
中图分类号
学科分类号
摘要
经调理酵母多糖(OPZ)刺激的大鼠肺泡巨噬细胞培养上清液可松弛豚鼠离体气管肌条,上清液中PGE1增加,表明PGE1是肺泡巨噬细胞松弛气管肌条的介质之一。经OPZ激活的肺泡巨噬细胞培养上清液与豚鼠血小板作用后,其松弛效应被逆转为收缩效应,提示可能由于肺泡巨噬细胞分泌血小板活化因子激活血小板,使释放收缩介质所致。肺泡巨噬细胞借助所分泌的介质经常性地调节气道阻力,对肺通气具有保护意义。
引用
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页码:20 / 23
页数:4
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