核酸适配体在肿瘤诊断与治疗中的研究进展

被引：5

作者：

赵娟

顾月清

机构：

[1] 中国药科大学生命科学与技术学院

来源：

药物生物技术 | 2013年 / 20卷 / 04期

关键词：

肿瘤相关因子; 核酸适配体; 肿瘤诊断与治疗;

D O I：

10.19526/j.cnki.1005-8915.2013.04.021

中图分类号：

R730.4 [肿瘤诊断学];

学科分类号：

100214 ;

摘要：

核酸适配体(aptamer)又称核酸适配子,是利用指数富集的配体系统进化技术(systematic evolution of ligands by exponential enrichrnent,SELEX)通过随机寡核苷酸文库与靶物质结合,经过多轮的筛选和扩增,得到的单链DNA或RNA,具有高亲和力,能特异性地结合靶物质。由于核酸适配体具有靶标分子范围广,自身分子质量小,对靶物质有高亲和力、特异性等特点,得到了研究者的广泛关注,逐渐应用于分析化学、蛋白质组学等学科,涉及到的技术手段有生物传感器、生物芯片等。适配体作为一种新型的药物分子在肿瘤领域应用研究也逐渐增多,在肿瘤诊断和治疗上起到了重要的作用。文章总结了近年来肿瘤相关因子的核酸适配体在肿瘤诊断与治疗中的研究情况。

引用

页码：369 / 372

页数：4

共 12 条

[1] An aptamer based resonance light scattering assay of prostate specific antigen [J].

Chen, Zhanguang ;

Lei, Yulong ;

Chen, Xi ;

Wang, Zhen ;

Liu, Jinbin .

BIOSENSORS & BIOELECTRONICS, 2012, 36 (01) :35-40

[2] A "signal-on" electrochemical aptasensor for simultaneous detection of two tumor markers [J].

Zhao, Jing ;

He, Xiaolin ;

Bo, Bing ;

Liu, Xinjian ;

Yin, Yongmei ;

Li, Genxi .

BIOSENSORS & BIOELECTRONICS, 2012, 34 (01) :249-252

[3] Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells [J].

Meyer, Cindy ;

Eydeler, Katja ;

Magbanua, Eileen ;

Zivkovic, Tijana ;

Piganeau, Nicolas ;

Lorenzen, Inken ;

Groetzinger, Joachim ;

Mayer, Guenter ;

Rose-John, Stefan ;

Hahn, Ulrich .

RNA BIOLOGY, 2012, 9 (01) :67-80

[4] Aptamer-quantum dots conjugates-based ultrasensitive competitive electrochemical cytosensor for the detection of tumor cell [J].

Li, Jingjing ;

Xu, Mi ;

Huang, Haiping ;

Zhou, Jinjun ;

Abdel-Halim, E. S. ;

Zhang, Jian-Rong ;

Zhu, Jun-Jie .

TALANTA, 2011, 85 (04) :2113-2120

[5]

Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein[J] . Young Ju Lee,Seong-Wook Lee.Biochemical and Biophysical Research Communications . 2011 (1)

[6] Increased Vascular Delivery and Efficacy of Chemotherapy after Inhibition of Platelet-Derived Growth Factor-B [J].

Falcon, Beverly L. ;

Pietras, Kristian ;

Chou, Jeyling ;

Chen, Debbie ;

Sennino, Barbara ;

Hanahan, Douglas ;

McDonald, Donald M. .

AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (06) :2920-2930

[7]

Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (?) prostate cancers[J] . Kyoungin Min,Hunho Jo,Kyungmi Song,Minseon Cho,Yang-Sook Chun,Sangyong Jon,Won Jong Kim,Changill Ban.Biomaterials . 2010 (8)

[8] Selection of DNA aptamer against prostate specific antigen using a genetic algorithm and application to sensing [J].

Savory, Nasa ;

Abe, Koichi ;

Sode, Koji ;

Ikebukuro, Kazunori .

BIOSENSORS & BIOELECTRONICS, 2010, 26 (04) :1386-1391

[9] Inhibition of In vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer [J].

Sarraf-Yazdi, Shiva ;

Mi, Jing ;

Moeller, Benjamin J. ;

Niu, Xilin ;

White, Rebekah R. ;

Kontos, Christopher D. ;

Sullenger, Bruce A. ;

Dewhirst, Mark W. ;

Clary, Bryan M. .

JOURNAL OF SURGICAL RESEARCH, 2008, 146 (01) :16-23

[10]

Selection of DNA aptamer that specific binding human carcinoembryonic antigen in vitro 1 1 This work was supported by the China National Natural Science Foundation(30670958)[J] . Lifeng Wang,Baorui Liu,Haitao Yin,Jia Wei,Xiaoping Qian,Lixia Yu.Journal of Nanjing Medical University . 2007 (5)

← 1 2 →