藁本内酯的稳定性与溶剂化效应的关系

被引：36

作者：

周长新

李新华

机构：

[1] 浙江大学化学系,浙江大学化工系浙江杭州,浙江杭州

来源：

药学学报 | 2001年 / 10期

关键词：

藁本内酯; 稳定性; 溶剂化效应;

D O I：

10.16438/j.0513-4870.2001.10.018

中图分类号：

TQ461 [中草药制剂的生产];

学科分类号：

1008 ;

摘要：

AIM To study the stability of ligustilide with solvent effect and try to disclose the relationship between its stability and solvent effect, so as to develop a useful method for its preservation. METHODS The model of PCM solvent effect was used to carry out quantum chemistry calculation. The GC/MS spectrum was used to study the stability of ligustilide in solvent at room temperature. RESULTS Ligustilide is more stable in cyclohexane and chloroform than in air. The isomerization rate of ligustilide decreased remarkably to 1 6% and 6 7% in cyclohexane and chloroform compared to 58% in air. CONCLUSION The stability of ligustilide is greatly improved with the solvent effect. Keeping ligustilide in proper organic solvent is helpful to prevent its isomerization.

引用

页码：793 / 795

页数：3

共 5 条

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