人参皂苷抗海马培养细胞缺氧损伤的作用(英文)

被引：5

作者：

王福庄

丁爱石

刘振伟

机构：

[1] 军事医学科学院基础医学研究所神经生物室,军事医学科学院基础医学研究所神经生物室,军事医学科学院基础医学研究所神经生物室北京中国,北京中国,北京中国

来源：

Acta Pharmacologica Sinica | 1995年 / 05期

关键词：

人参; 皂苷类; 缺氧症; 海马; 培养的细胞;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

目的:观察人参皂苷抗脑细胞缺氧损伤的作用.方法:将12d培龄的海马细胞置于95％N2+5％CO2中4—24h,比较人参皂苷组和对照组细胞形态学.存活率及LDH和K+流出的变化.结果:缺氧24h后,对照细胞存活率从缺氧前92％±4％降至1.0％±2.0％;LDH和K+漏出量分别由2.3±0.6 U L-1和5.56±0.16 mmol L-1增至36±5 U L-1和8.5±0.7 mmol L-1;此时,人参皂苷组细胞存活率为4％±4％;LDH漏出量为30+3 U L-1,K+含量为7.9士0.8 mmol L1.与对照组相比,人参皂苷组受损程度明显减轻.结论:人参皂苷具有抗海马细胞缺氧损伤的作用.

引用

页码：37 / 40+99

页数：5

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