溃疡性结肠炎发病机制研究进展

被引：197

作者：

赵曼 ^{[1
]}

高峰 ^{[2
]}

机构：

[1] 新疆医科大学

[2] 新疆维吾尔自治区人民医院消化科

来源：

现代生物医学进展 | 2010年 / 10卷 / 16期

关键词：

溃疡性结肠炎; 发病机制; 免疫因素; 遗传因素;

D O I：

10.13241/j.cnki.pmb.2010.16.030

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

溃疡性结肠炎是一种常见的慢性肠道疾病,近年来发病呈上升趋势,而其发病机制目前尚不明确,目前认为与多种因素有关。其中免疫异常被认为是该病发病的重要因素,主要包括自身抗体、细胞免疫、细胞因子、环氧合酶与基质金属蛋白酶、氧自由基和一氧化氮等。但是遗传因素,感染因素,精神因素,饮食因素等均在其发生和发展中亦起着一定作用。本文就溃疡性结肠炎发病机制的各种影响因素予以综述。

引用

收藏

页码：3160 / 3165

页数：6

相关论文

共 29 条

[1]

Matrilysin controls neutrophil location in ulcerative colitis.[J].M. Swee;J;.K. McGuire;Y. Wang;C.L. Wilson;W.C. Parks.Matrix Biology.2006,

[2]

The alternative NF-κB pathway from biochemistry to biology:: Pitfalls and promises for future drug development [J].

Dejardin, Emmanuel .

BIOCHEMICAL PHARMACOLOGY, 2006, 72 (09) :1161-1179

[3]

Expression of matrix metalloproteinases-2 and-9 in intestinal tissue of patients with inflammatory bowel diseases [J].

Gao, Q ;

Meijer, MJW ;

Kubben, FJGM ;

Sier, CFM ;

Kruidenier, L ;

van Duijn, W ;

van den Berg, M ;

van Hogezand, RA ;

Lamers, CBHW ;

Verspaget, HW .

DIGESTIVE AND LIVER DISEASE, 2005, 37 (08) :584-592

[4]

Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts [J].

Andoh, A ;

Zhang, ZB ;

Inatomi, O ;

Fujino, S ;

Deguchi, Y ;

Araki, Y ;

Tsujikawa, T ;

Kitoh, K ;

Kim-Mitsuyama, S ;

Takayanagi, A ;

Shimizu, N ;

Fujiyama, Y .

GASTROENTEROLOGY, 2005, 129 (03) :969-984

[5]

Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution [J].

Heller, F ;

Florian, P ;

Bojarski, C ;

Richter, J ;

Christ, M ;

Hillenbrand, B ;

Mankertz, J ;

Gitter, AH ;

Bürgel, N ;

Fromm, M ;

Zeitz, M ;

Fuss, I ;

Strober, W ;

Schulzke, JD .

GASTROENTEROLOGY, 2005, 129 (02) :550-564

[6]

Characteristics of intestinal dendritic cells in inflammatory bowel diseases [J].

Hart, AL ;

Al-Hassi, HO ;

Rigby, RJ ;

Bell, SJ ;

Emmanuel, AV ;

Knight, SC ;

Kamm, MA ;

Stagg, AJ .

GASTROENTEROLOGY, 2005, 129 (01) :50-65

[7]

Peripheral and intestinal regulatory CD4+CD25high T cells in inflammatory bowel disease [J].

Maul, J ;

Loddenkemper, C ;

Mundt, P ;

Berg, E ;

Giese, T ;

Stallmach, A ;

Zeitz, M ;

Duchmann, R .

GASTROENTEROLOGY, 2005, 128 (07) :1868-1878

[8]

Transgenic over-expression of macrophage migration inhibitory factor renders mice markedly more susceptible to experimental colitis [J].

Ohkawara, T ;

Miyashita, K ;

Nishihira, J ;

Mitsuyama, K ;

Takeda, H ;

Kato, M ;

Kondo, N ;

Yamasaki, Y ;

Sata, M ;

Yoshiki, T ;

Sugiyama, T ;

Asaka, M .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 140 (02) :241-248

[9]

Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice [J].

Cosnes, J .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2004, 18 (03) :481-496

[10]

消化系疾病基础与临床进展.[M].萧树东主编;.上海科学技术文献出版社.2005,