红细胞钠-锂逆向转运活性与糖尿病肾病关系的研究

被引：2

作者：

杨涛

陈家伟

赵人琤

戴建国

杨永年

机构：

[1] 南京医科大学第一附属医院内分泌科!

[2] 南京医科大学应用毒理研究所

[3] 上海医科大学附属中山医院内分泌科

来源：

中华内分泌代谢杂志 | 1999年 / 04期

基金：

国家科技攻关计划;

关键词：

糖尿病肾病; 红细胞钠-锂逆向转运;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

1002 ; 100201 ;

摘要：

目的　探讨红细胞钠锂逆向转运（ＳＬＣ）活性在糖尿病肾病（ＤＮ）发病中的作用及其对ＤＮ的预测价值。方法　采用Ｚｅｒｂｉｎｉ最新提出的６００ｍｍｏｌ／Ｌ法，测定正常对照２４例、原发性高血压２６例及２型糖尿病８５例ＳＬＣ活性。糖尿病组按尿白蛋白／肌酐比值分为正常、微量和大量白蛋白尿组。结果　原发性高血压组（Ｐ＜０．００１）和糖尿病组（Ｐ＜０．００１）ＳＬＣ活性明显高于正常对照组，微量白蛋白尿组（Ｐ＜０．０１）和大量白蛋白尿组（Ｐ＜０．００５）ＳＬＣ活性明显高于正常白蛋白尿组。多元线性逐步回归分析显示ＳＬＣ活性、病程、平均血压、甘油三酯为尿白蛋白／肌酐比值升高的独立危险因素。结论　ＳＬＣ活性增高是糖尿病肾病发生的主要危险因素之一，可作为糖尿病肾病的易感指标，有一定的预测价值，但缺乏特异性和敏感性。

引用

页码：14 / 17

页数：4

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