基于网络药理学芪葵颗粒治疗糖尿病肾病的物质基础及作用机制研究

被引：45

作者：

浦强 ^{[1
]}

徐巍龙 ^{[2
]}

李楠 ^{[1
]}

王丽娟 ^{[2
]}

余江毅 ^{[2
]}

机构：

[1] 南京中医药大学附属医院

[2] 江苏省中医院

来源：

中草药 | 2019年 / 50卷 / 23期

关键词：

芪葵颗粒; 糖尿病肾病; 网络药理学; 靶点; IL-17信号通路; HIF-1信号通路; TNF信号通路;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的运用网络药理学方法研究芪葵颗粒治疗糖尿病肾病(DN)的多成分、多靶点、多通路作用机制,旨在为其基础研究及临床应用提供依据。方法通过多个数据库检索并筛选芪葵颗粒活性成分和其作用DN相关靶点,并通过Cytoscape软件分别构建药物、靶点、疾病靶点网络图,利用网络拓扑分析芪葵颗粒治疗DN关键靶点,采用ClueGO插件进行GO、KEGG基因富集分析,得到芪葵颗粒治疗DN的潜在作用通路。结果芪葵颗粒中筛选得到67个活性成分,涉及DN作用靶点212个。网络拓扑分析最终筛选出43个关键靶点,ClueGO富集分析关键靶点主要被富集在IL-17信号通路、HIF-1信号通路、TNF信号通路等49个显著相关通路,涉及神经递质代谢过程、小分子代谢过程、血压和氧化还原酶活性调节等132个显著相关生物过程。结论芪葵颗粒有效成分可调控DN发病重要通路中多个靶点。

引用

页码：5767 / 5777

页数：11

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