基质金属蛋白酶及其抑制物与原发性高血压

被引:5
作者
李超民
拓步雄
机构
[1] 西安市解放军第中心医院心内科
关键词
基质金属蛋白酶; MMPS; 高血压心脏病; MMPs; 高血压性心力衰竭; MMPI; TIMP; 高血压患者; 他汀类降脂药; 单纯收缩期高血压; 抑制物;
D O I
10.16439/j.cnki.1673-7245.2008.09.005
中图分类号
R544.1 [高血压];
学科分类号
1002 ; 100201 ;
摘要
<正> 基质金属蛋白酶(matrix metalloproteinase,MMPs)是参与降解全身各种组织细胞外基质(extra-cellular matrix,ECM)的蛋白酶家族,参与正常和病理条件下的组织重构。组织金属蛋白酶抑制物(TIMP)是 MMPs 的特异性抑制物。近年来随着对 MMPs/
引用
收藏
页码:779 / 781
页数:3
相关论文
共 11 条
[1]   Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats [J].
Gianella, Anita ;
Nobili, Elena ;
Abbate, Mauro ;
Zoja, Carla ;
Gelosa, Paolo ;
Mussoni, Luciana ;
Bellosta, Stefano ;
Canavesi, Monica ;
Rottoli, Daniela ;
Guerrini, Uliano ;
Brioschi, Maura ;
Banfi, Cristina ;
Tremoli, Elena ;
Remuzzi, Giuseppe ;
Sironi, Luigi .
AMERICAN JOURNAL OF PATHOLOGY, 2007, 170 (04) :1165-1177
[2]   Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure [J].
Saka, Masako ;
Obata, Koji ;
Ichihara, Sahoko ;
Cheng, Xian Wu ;
Kimata, Hirotaka ;
Nishizawa, Takao ;
Noda, Akiko ;
Izawa, Hideo ;
Nagata, Kohzo ;
Murohara, Toyoaki ;
Yokota, Mitsuhiro .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2006, 47 (06) :770-779
[3]  
Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases: Relationship Between Changes in Proteolytic Determinants of Matrix Composition and Structural, Functional, and Clinical Manifestations of Hypertensive Heart Disease[J] . S Hinan Ahmed,Leslie L. Clark,Weems R. Pennington,Carson S. Webb,D Dirk Bonnema,Amy H. Leonardi,Catherine D. McClure,Francis G. Spinale,Michael R. Zile.Circulation . 2006 (17)
[4]   Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload [J].
Matsusaka, H ;
Ide, T ;
Matsushima, S ;
Ikeuchi, M ;
Kubota, T ;
Sunagawa, K ;
Kinugawa, S ;
Tsutsui, H .
HYPERTENSION, 2006, 47 (04) :711-717
[5]  
Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade[J] . James P Spiers,Elizabeth J Kelso,Wei F Siah,Gillian Edge,Guojie Song,Barbara J McDermott,Martina Hennessy.Journal of Hypertension . 2005 (9)
[6]   Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition [J].
Bouvet, C ;
Gilbert, LA ;
Girardot, D ;
deBlois, D ;
Moreau, P .
HYPERTENSION, 2005, 45 (03) :432-437
[7]   Downregulation of vascular matrix metalloproteinase inducer and activator proteins in hypertensive patients [J].
Ergul, A ;
Portik-Dobos, V ;
Hutchinson, J ;
Franco, J ;
Anstadt, MP .
AMERICAN JOURNAL OF HYPERTENSION, 2004, 17 (09) :775-782
[8]  
Activation of Matrix Metalloproteinases Precedes Left Ventricular Remodeling in Hypertensive Heart Failure Rats: Its Inhibition as a Primary Effect of Angiotensin-Converting Enzyme Inhibitor[J] . Yasushi Sakata,Kazuhiro Yamamoto,Toshiaki Mano,Nagahiro Nishikawa,Junichi Yoshida,Masatsugu Hori,Takeshi Miwa,Tohru Masuyama.Circulation: Journal of the American Heart Association . 2004 (17)
[9]   Pressure-induced matrix metalloproteinase-9 contributes to early hypertensive remodeling [J].
Lehoux, S ;
Lemarié, CA ;
Esposito, B ;
Lijnen, HR ;
Tedgui, A .
CIRCULATION, 2004, 109 (08) :1041-1047
[10]  
Extracellular matrix biology: a new frontier in linking the pathology and therapy of hypertension?[J] . Muzahir H Tayebjee,Robert J MacFadyen,Gregory YH Lip.Journal of Hypertension . 2003 (12)