靶控输注异丙酚的临床应用和准确性评价

被引：63

作者：

张马忠

王珊娟

杭燕南

吴健

机构：

[1] 上海第二医科大学附属仁济医院麻醉科

[2] 浙江大学医学院附属第一医院麻醉科

来源：

中华麻醉学杂志 | 2002年 / 11期

关键词：

药代动力学; 二异丙酚; 评价研究; 靶控输注;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

目的评估内嵌Marsh等报道的药代学参数的TCI系统的准确性。方法22例ASAⅠ～Ⅱ级择期手术患者,<65岁(Y组)和>65岁(E组)各11例,异丙酚靶浓度从2μg/ml开始以1μg/ml递增直至意识消失,分析血浆浓度。计算每个样本的百分比预测误差(％PE)、稳定误差(％CE)和组间个体内中位数预测误差(MDPE)、中位数绝对误差(MDAPE)、中位数稳定误差(MDCE)、中位数绝对稳定误差(MDACE)。结果升高靶浓度时系统产生明显的超射。E组异丙酚血浆浓度的PE和绝对值PE分别是63.3％和66.2％,Y组则分别是62.1％和62.7％。E组CE和绝对值CE分别是-0.3％和12.7％,Y组则分别是0.6％和13.5％,组间无差异(P>0.05)。E组和Y组中位数MDPE(=中位数MDAPE)分别为78.1％和66.1％,MDCE分别是-0.2％和0.8％,MDACE分别是12.5％和13.5％。实测浓度和预测浓度呈显著直线相关(P<0.01)。结论Marsh参数用于国人靶控输注,实测浓度和预测浓度的差异性较大,但系统能够维持稳定的血浆浓度。

引用

页码：20 / 23

页数：4

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