腺苷和ATP对大鼠肾脏缺血再灌注损伤保护作用的比较

被引：11

作者：

严博泉

姜佑三

权昌益

刘少青

不详

机构：

[1] 延边大学医学院附属医院泌尿外科!延吉

[2] 山东沂水医院!延边大学医学院级泌尿外科

来源：

中国现代医学杂志 | 2000年 / 10期

关键词：

肾脏; 腺苷; ATP; 缺血再灌注; 保护机制;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

目的 :探讨腺苷和ATP对肾脏缺血再灌注损伤的保护作用机制并进行相互比较。方法 :将大鼠随机分为对照组 (CON)、缺血再灌注组 (IR)、给予ATP后缺血再灌注组 (ATP)和给予腺苷后缺血再灌注组 (AD) ,分别观察各组中在再灌注 0h、2h和 6h的Na+和K+-ATP酶和Ca2 +-ATP酶活性的变化 ,以及组织病理变化。结果 :病理学组织学肾小管评分 ,腺苷组和CON组之间无显著性差异 (P >0 .0 5 ) ,但两组均明显低于IR组和ATP组 (P <0 .0 5或P <0 .0 1) ,IR组和ATP组之间无显著差异 (P >0 .0 5 )。Na+,K+-ATP酶和Ca2 +-ATP酶的活性 ,在腺苷组和CON组之间无显著性差别 ,(P >0 .0 5 ) ,但两组均明显高于IR组和ATP组 (P <0 .0 1) ,而IR组和ATP组之间无显著性差异 (P >0 .0 5 )。结论 :腺苷对大鼠肾脏缺血再灌注损伤没有保护作用 ,ATP对大鼠肾脏缺血再灌注损伤有保护作用。

引用

页码：12 / 14+113 +113-114

页数：5

共 15 条

[1]

Angiotensin converting enzyme inhibition and tubular necrosis. Burke TJ,Schrier RW. Kidney International . 1987

[2]

Intracoronary adenosine administered after reperfusion limits vascular injury after prolonged ischemia in the canine model. Babbit DG,Virmain R,Firman MB. Circulation . 1989

[3]

The effects of adenosine agonists on human neutrrophil function. Schrier DJ,Imre KM. J Immunol . 1986

[4]

The adenosine neutrophil paradox resolved; human neutrophils possess both A1 receptors and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. Cronstein NB,Daguma L,Nichols D,et al. The Journal of Clinical Investigation . 1990

[5]

Adenosine: a physiologic modulztor of superoxide anion generation by human neutrophils. Cronstein BN,Kramer SB,Weissmann G,et al. The Journal of Experimental Medicine . 1983

[6]

Patogenesisandmodificationofmyocardialreperfusioninjury. FormanMB,VirmaniR. . 1991

[7]

Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of endothelium and the "no- reflow"Phenomenon. Olassson B,Forman MB,Puett DW,et al. Circulation . 1987

[8]

Membrance adenosine triphosphate and cation transport. Glynn IM. British Medical Bulletin . 1968

[9]

Oxygen free radicals in ischemic acute renal failure in the rat. Paller MS. The Journal of Clinical Investigation . 1984

[10]

Method used to study the involvement of adenosine in the regulation of lipolysis.In: paton DM, ed. Fredholm BB. Methods in Pharmacology . 1985

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