胃癌遗传学及表遗传学研究进展

被引：15

作者：

陆俊骏 ^{[1
]}

钱烨 ^{[2
]}

连强 ^{[1
]}

机构：

[1] 上海中医药大学附属上海市中医医院肿瘤科

[2] 上海市中医药大学附属岳阳中西医结合医院内科

来源：

中国医药导报 | 2013年 / 10卷 / 19期

关键词：

胃癌; 遗传学; 表观遗传学; 非编码RNA; DNA甲基化; 组蛋白修饰;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

胃癌是病死率较高的恶性肿瘤之一,其发生与发展是多种因素交互作用的结果,包括环境、饮食、遗传、幽门螺杆菌感染、慢性炎症浸润、癌前病变等。随着对胃癌研究的不断深入,目前研究的焦点主要集中在遗传学及表观遗传学改变,包括DNA甲基化、组蛋白修饰、非编码RNA的改变、基因突变、基因杂合丢失和微卫星不稳定等。本文就遗传学及表遗传学改变在胃癌的诊断、预后预测及治疗等方面的研究进展做一综述。

引用

收藏

页码：43 / 46

页数：4

相关论文

共 19 条

[1]

Up-regulated expression of sulfatases (SULF1 and SULF2) as prognostic and metastasis predictive markers in human gastric cancer [J].

Hur, Keun ;

Han, Tae-Su ;

Jung, Eun-Jung ;

Yu, Jieun ;

Lee, Hyuk-Joon ;

Kim, Woo Ho ;

Goel, Ajay ;

Yang, Han-Kwang .

JOURNAL OF PATHOLOGY, 2012, 228 (01) :88-98

[2]

microRNA-146a targets the L1 cell adhesion molecule and suppresses the metastatic potential of gastric cancer [J].

Hou, Zhibo ;

Yin, Haitao ;

Chen, Cong ;

Dai, Xinzheng ;

Li, Xiaolin ;

Liu, Baorui ;

Fang, Xuefeng .

MOLECULAR MEDICINE REPORTS, 2012, 6 (03) :501-506

[3]

Clinical Significance of SOD2 and GSTP1 Gene Polymorphisms in Chinese Patients With Gastric Cancer [J].

Xu, Zhi ;

Zhu, Haixia ;

Luk, John M. ;

Wu, Dongmei ;

Gu, Dongying ;

Gong, Weida ;

Tan, Yongfei ;

Zhou, Jianwei ;

Tang, Jinhai ;

Zhang, Zhengdong ;

Wang, Meilin ;

Chen, Jinfei .

CANCER, 2012, 118 (22) :5489-5496

[4]

p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population [J].

Song, Hye-Rim ;

Kweon, Sun-Seog ;

Kim, Hee Nam ;

Piao, Jin-Mei ;

Yun, Woo-Jun ;

Choi, Jin-Su ;

Hwang, Jun-Eul ;

Yoon, Ju-Young ;

Kim, Hyeong-Rok ;

Park, Young-Kyu ;

Kim, Soo-Hyun ;

Choi, Yoo-Duk ;

Shin, Min-Ho .

GASTRIC CANCER, 2011, 14 (03) :242-247

[5]

Methylation of BNIP3 and DAPK indicates lower response to chemotherapy and poor prognosis in gastric cancer [J].

Sugita, Hirofumi ;

Iida, Satoru ;

Inokuchi, Mikito ;

Kato, Keiji ;

Ishiguro, Megumi ;

Ishikawa, Toshiaki ;

Takagi, Yoko ;

Enjoji, Megumu ;

Yamada, Hiroyuki ;

Uetake, Hiroyuki ;

Kojima, Kazuyuki ;

Sugihara, Kenichi .

ONCOLOGY REPORTS, 2011, 25 (02) :513-518

[6]

Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation [J].

Fehri, Lina Fassi ;

Rechner, Cindy ;

Janssen, Sabrina ;

Mak, Tim Nam ;

Holland, Carsten ;

Bartfeld, Sina ;

Bruegemann, Holger ;

Meyer, Thomas F. .

EPIGENETICS, 2009, 4 (08) :577-586

[7]

Glutathione S-Transferase T1 (GSTT1) Gene Polymorphism and Gastric Cancer Susceptibility: A Meta-Analysis of Epidemiologic Studies [J].

Chen, Bo ;

Cao, Lei ;

Zhou, Yong ;

Yang, Ping ;

Wan, Hong-Wei ;

Jia, Gui-Qing ;

Liu, Liu ;

Wu, Xiao-Ting .

DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (07) :1831-1838

[8]

Nature meets nurture: molecular genetics of gastric cancer [J].

Milne, Anya N. ;

Carneiro, F. ;

O'Morain, C. ;

Offerhaus, G. J. A. .

HUMAN GENETICS, 2009, 126 (05) :615-628

[9]

Aberrant CpG Island Hypermethylation of RASSF1A in Gastric Cardia Adenocarcinoma [J].

Guo, Wei ;

Dong, Zhiming ;

Chen, Zhifeng ;

Yang, Zhibin ;

Wen, Denggui ;

Kuang, Gang ;

Guo, Yanli ;

Shan, Baoen .

CANCER INVESTIGATION, 2009, 27 (04) :459-465

[10]

Epigenetics in bladder cancer [J].

Enokida, Hideki ;

Nakagawa, Masayuki .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2008, 13 (04) :298-307