糖尿病肾病的发病机制及抗糖尿病肾病化合物的研究进展

被引:33
作者
吕萌
胡高云
涂志军
余祖滔
周锟
李乾斌
机构
[1] 中南大学药学院药物化学系
关键词
糖尿病肾病; 发病机制; 抗糖尿病肾病化合物; 构效关系;
D O I
暂无
中图分类号
R587.2 [糖尿病性昏迷及其他并发症];
学科分类号
100201 [内科学];
摘要
糖尿病肾病(diabetic nephropathy,DN)是糖尿病最常见的并发症之一。近年来,随着世界范围内糖尿病患病率的上升,DN已成为威胁人类健康的一大杀手。DN的发病机制十分复杂。越来越多的研究表明,在个体差异的基础上,高血糖、高血压等引发的氧化应激、炎症反应和纤维化过程在DN的发生发展中起到了重要作用。因此,简单地控制高血糖、高血压、高血脂以及限制蛋白的摄入等基础治疗已经不足以控制DN的发生发展,针对氧化应激、炎症反应及纤维化等DN病理过程的药物开发将是抗DN药物研究的重点。本文就DN的发病机制及针对发病机制的抗DN化合物的结构、构效关系进行了综述。
引用
收藏
页码:1139 / 1145
页数:7
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Novel insights into the structural requirements for the design of selective and specific aldose reductase inhibitors[J] Hirdesh Kumar;Anup Shah;M. Sobhia Journal of Molecular Modeling 2012,
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[4]
NADPH oxidase inhibitors: a patent review[J] Jung-Ae Kim;Ganesh Prasad Neupane;Eung Seok Lee;Byeong-Seon Jeong;Byung Chul Park;Pritam Thapa Expert Opinion on Therapeutic Patents 2011,
[5]
NADPH Oxidase Inhibitors: New Antihypertensive Agents?[J] Holly C Williams;Kathy K Griendling Journal of Cardiovascular Pharmacology 2007,
[6]
Inflammatory Cells in Renal Injury and Repair[J] David Ferenbach;David C. Kluth;Jeremy Hughes Seminars in Nephrology 2007,
[7]
Permeability characteristics of novel aldose reductase inhibitors using rat jejunum in vitro[J] European Journal of Pharmaceutical Sciences 2006,
[8]
Aldose reductase inhibition alters nodal Na+ currents and nerve conduction in human diabetics[J] S Misawa;S Kuwabara;K Kanai;N Tamura;M Nakata;S Sawai;K Yagui;T Hattori Neurology 2006,
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[10]
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