阿尔茨海默病相关核心生物标志物研究进展

被引：22

作者：

陈逸

张宝荣

机构：

[1] 浙江大学医学院附属第二医院神经科

来源：

生命科学 | 2014年 / 26卷 / 01期

关键词：

阿尔茨海默病; 生物学标记物; β淀粉样蛋白; tau蛋白;

D O I：

10.13376/j.cbls/2014002

中图分类号：

R749.16 [];

学科分类号：

摘要：

阿尔茨海默病作为近年来患病率最高的中老年疾病之一,以导致患者认知功能障碍、记忆力减退、性格改变为主要表现,其神经病理学特点为老年斑和神经元内神经原纤维缠结等。此病起病隐袭,临床症状出现前即有相应的生物学标记物改变;而易检、高敏感性及高特异性的有效生物学标记物有助于疾病早期诊断和早期治疗,意义重大。通过综述目前较为成熟的阿尔茨海默病相关核心生物学标记物,以讨论其临床及科研应用价值并展望未来的发展趋势。

引用

页码：2 / 8

页数：7

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