急性血糖波动加剧氧化应激引起糖尿病微血管并发症的研究

被引：35

作者：

兰丽珍

弓军胜

谭芳

杨静

机构：

[1] 山西医科大学第一医院

来源：

中西医结合心脑血管病杂志 | 2013年 / 11卷 / 06期

关键词：

糖尿病; 微血管病变; 血糖波动; 氧化应激;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

目的观察2型糖尿病患者血糖波动幅度、氧化应激水平与糖尿病微血管病变的相关性。方法将106例2型糖尿病患者分为3组,无糖尿病微血管病变组(DM组);合并单一糖尿病微血管病变组(DA1组)包括糖尿病肾病或糖尿病糖尿病视网膜病变;同时合并糖尿病肾病与糖尿病视网膜病变组(DA2组),行口服葡萄糖耐量试验(OGTT),胰岛素释放,检测血脂、糖化血红蛋白(HbA1c)、丙二醛(MDA)等。结果 DA1组及DA2组的空腹及餐后2h血清MDA水平及△MDA值(2hMDA较0hMDA的增幅)均较DM组增加,差异有统计学意义(P<0.05),而且DA2组较DA1组升高,差异有统计学意义(P<0.05),△MDA与餐后血糖波动幅度(PPGE)、餐后2h血糖(2hPBG)浓度呈正相关(P<0.05)。结论血糖波动诱导氧化应激水平加剧,引起并加重2型糖尿病患者微血管病变。

引用

页码：678 / 680

页数：3

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