PD-1/PD-L1在非小细胞肺癌中表达的生物学作用及临床意义

被引:5
作者
彭苗
莫凯岚
王希成
丁颖
机构
[1] 广东药科大学附属第一医院肿瘤科
关键词
非小细胞肺癌; PD-1; PD-L1; EGFR;
D O I
暂无
中图分类号
R734.2 [肺肿瘤];
学科分类号
100117 [系统生物医学];
摘要
目的研究PD-1/PD-L1及EGFR在非小细胞肺癌中的表达和相关性。方法收集我院96例非小细胞肺癌患者的病理标本和临床资料,使用免疫组化检测PD-1/PD-L1的表达情况,PCR检测EGFR的表达情况。使用Logistic回归分析评价PD-1/PD-L1和EGFR的相关性。结果吸烟患者的PD-1阳性率为76.7%(23例),显著高于不吸烟患者的21.2%(14例)(P<0.05)。女性患者的PD-L1阳性率为82.0%(41例),显著高于男性的45.7%(21例)(P<0.05)。腺癌患者的PD-L1阳性率为78.3%(47例),显著高于鳞癌的41.7%(15例)(P<0.05)。EGFR突变型患者的PD-L1阳性率为91.9%(34例),显著高于野生型的47.5%(28例)(P<0.05)。结论 PD-1在吸烟患者中高表达;PD-L1与EGFR呈正相关,且在女性、腺癌患者中高表达,PD-L1与EGFR基因表达的关系可能为个体化免疫治疗联合靶向治疗提供新的依据。
引用
收藏
页码:915 / 917
页数:3
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