银杏苦内酯B对家兔内毒素休克心功能抑制的防治作用研究

被引:3
作者
杜文华
陈惠孙
胡德耀
陆松敏
机构
[1] 第三军医大学大坪医院野战外科研究所一室
[2] 第三军医大学大坪医院野战外科研究所一室 重庆
[3] 重庆
关键词
内毒素休克; 银杏苦内酯B; 血小板活化因子;
D O I
10.13412/j.cnki.zyyl.1996.06.006
中图分类号
R285.5 [中药实验药理];
学科分类号
1008 ;
摘要
家兔内毒素休克时 MAP、LVSP、dp/dtmax、IP 和 Lo 等显著降低,此变化与血中PAF 水平呈显著的负相关。PAF 受体拮抗剂银杏苦内酯 B 预处理后能有效逆转内毒素引起的心血管功能紊乱的表现,表明 PAF 可能在内毒素休克早期的心血管功能紊乱中具有重要作用,PAF受体拮抗剂银杏苦内酯 B 具有明显的预防保护作用。
引用
收藏
页码:11 / 14
页数:4
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