青年难治性抑郁症患者重复经颅磁刺激治疗研究

被引：17

作者：

郑会蓉 ^{[1
]}

张丽 ^{[1
]}

赵巍峰 ^{[2
]}

邹娟 ^{[1
]}

傅锦华 ^{[1
,3
]}

李凌江 ^{[1
]}

机构：

[1] 中南大学湘雅二医院精神卫生研究所

[2] 深圳市南山区慢性病防治院

[3] 湖南省脑科医院精神科

来源：

中国临床心理学杂志 | 2010年 / 18卷 / 01期

关键词：

rTMS; 难治性抑郁症; 匹茨堡睡眠质量指数量表;

D O I：

10.16128/j.cnki.1005-3611.2010.01.017

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

目的:探讨高频重复经颅磁刺激(rTMS)对单相难治性抑郁症的治疗价值和安全性。方法:36例青年难治性抑郁症患者随机分为真刺激组及药物治疗组,共接受20次rTMS治疗。治疗开始及疗程结束时使用汉密尔顿抑郁量表(HAMD)、贝克抑郁自评量表(BDI)、大体功能评定量表(GAF)及匹茨堡睡眠质量指数量表(PSQI)评定疗效。结果:治疗结束后,磁刺激组有效12例,其中痊愈4例,有效率为63.2%。药物组有效2例,有效率11.8%。卡方值为14,P=0.000。rTMS组治疗后,患者HAMD评分从治疗前(24.68±3.01)分降低到(13.53±5.19),药物组HAMD评分治疗前(24.47±2.62),治疗后(20.88±4.30)。两组治疗后HAMD评分有显著性差异(P<0.01)。治疗后,rTMS组的BDI、GAF及PSQI评分也明显低于单纯药物组,两组症状改善状况差异明显(P<0.05)。结论:重复经颅磁刺激合并抗抑郁药物治疗难治性抑郁症安全有效。

引用

页码：44 / 46

页数：3

共 8 条

[1]

Amino Acid Neurotransmitters Assessed by Proton Magnetic Resonance Spectroscopy: Relationship to Treatment Resistance in Major Depressive Disorder[J] . Rebecca B. Price,Dikoma C. Shungu,Xiangling Mao,Paul Nestadt,Chris Kelly,Katherine A. Collins,James W. Murrough,Dennis S. Charney,Sanjay J. Mathew.Biological Psychiatry . 2009 (9)

[2] What is the meaning of treatment resistant/refractory major depression (TRD)? A systematic review of current randomized trials [J].

Berlim, Marcelo T. ;

Turecki, Gustavo .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2007, 17 (11) :696-707

[3]

Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial[J] . John P. O’Reardon,H. Brent Solvason,Philip G. Janicak,Shirlene Sampson,Keith E. Isenberg,Ziad Nahas,William M. McDonald,David Avery,Paul B. Fitzgerald,Colleen Loo,Mark A. Demitrack,Mark S. George,Harold A. Sackeim.Biological Psychiatry . 2007 (11)

[4] Tolerability and safety of high daily doses of repetitive transcranial magnetic stimulation in healthy young men [J].

Anderson, B ;

Mishory, A ;

Nahas, Z ;

Borckardt, JJ ;

Yamanaka, K ;

Rastogi, K ;

George, MS .

JOURNAL OF ECT, 2006, 22 (01) :49-53

[5] A randomized controlled comparison of electroconvulsive therapy and repetitive transcranial magnetic stimulation in severe and resistant nonpsychotic major depression [J].

Grunhaus, L ;

Schreiber, S ;

Dolberg, OT ;

Polak, D ;

Dannon, PN .

BIOLOGICAL PSYCHIATRY, 2003, 53 (04) :324-331

[6]

Chapter 42 Prefrontal cortex stimulation as antidepressant treatment: mode of action and clinical effectiveness of rTMS[J] . Supplements to Clinical Neurophysiology . 2003

[7] A controlled trial of daily left prefrontal cortex TMS for treating depression [J].