响应曲面模型在麻醉药合用中药物-药物相互作用研究的进展

被引：3

作者：

管峥 ^{[1
]}

毕姗姗 ^{[1
]}

杨璐 ^{[2
]}

张利萍 ^{[2
]}

周田彦 ^{[1
]}

卢炜 ^{[1
,3
]}

机构：

[1] 北京大学药学院

[2] 北京大学第三医院

[3] 北京大学天然药物及仿生药物国家重点实验室

来源：

药学学报 | 2008年 / 12期

关键词：

响应曲面模型; 麻醉药物; 药物-药物相互作用;

D O I：

10.16438/j.0513-4870.2008.12.012

中图分类号：

R969.2 [药物相互作用];

学科分类号：

100602 ; 100706 ;

摘要：

响应曲面法是一种研究药物-药物相互作用的有效而新颖的方法。当两种药物以不同比例合用时,这种方法可表述药效响应曲面的关键特征,发现曲面中的响应最优区域,揭示药物间相互作用的机制,以达到指导临床合理用药,降低用药风险和用药成本的目的。本文以麻醉药为例介绍了响应曲面法的相关概念、模型结构及其在模型化解析和临床实践中研究的进展。

引用

页码：1171 / 1178

页数：8

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