NF-κB-IKKβ通路作为药物开发靶点的研究现状

被引：17

作者：

魏晓炎 ^{[1
]}

侯乐萍 ^{[2
]}

机构：

[1] 浙江省肿瘤医院药剂科

[2] 杭州市老年病医院药剂科

来源：

现代医药卫生 | 2018年 / 34卷 / 19期

关键词：

核因子F-κB; 蛋白酶抑制药; 炎症; 细胞凋亡; 肿瘤; 综述;

D O I：

暂无

中图分类号：

R91 [药物基础科学];

学科分类号：

100705 [微生物与生化药学];

摘要：

<正>核因子κB(NF-κB)是人体抗感染的第一道防线,NF-κB作为转录因子,调控大量不同基因组的转录。IKKβ是NF-κB重要的上游激酶,NF-κB-IKKβ通路的激活导致细胞因子、趋化因子与其各自受体的产生,参与了免疫调节、炎症、细胞凋亡、细胞增殖和存活、血管生成、癌症发生和转移等[1]。通过研发药物阻断NF-κB-IKKβ通路,可以治疗肿瘤和炎症相关的多种疾病,大量的制药公司和科研机

引用

页码：2992 / 2995

页数：4

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