乙型肝炎患者血清白细胞介素6和血小板源生长因子水平与肝纤维化关系

被引:15
作者
彭小斌
张国安
刘小朋
陈紫榕
施水兰
机构
[1] 解放军医院传染科!福州
关键词
乙型肝炎; 白细胞介素6; 血小板源生长因子; 肝纤维化;
D O I
暂无
中图分类号
R512.62 [];
学科分类号
100401 ;
摘要
采用酶联免疫吸附试验 (ELISA)和细胞生物活性法检测了 80例乙型肝炎患者白细胞介素 6 (IL - 6 )和血小板源生长因子 (PDGF)水平 ,结果表明 :急性肝炎、慢性肝炎和肝硬化患者的IL - 6和PDGF的活性明显高于正常对照组 ,且与患者的血清Ⅲ型前胶原肽 (PCⅢ )含量密切相关 ,揭示IL - 6和PDGF活性的变化可能与肝纤维化的发病机制有关
引用
收藏
页码:37 / 40
页数:2
相关论文
共 5 条
[1]  
Iteraction of Immune and connective tissue cell.Theeffect of Lymphokines and monokines on fibroblast growth. Thornton SC. Journal of Leukocyte Biology . 1990
[2]  
Effect of cytokines on the liver. Andus T,Fauer J,Gerok W. Hepatology . 1991
[3]  
The response of rat liverperisinasoidal lipocyte to polypeptide growth regulator changes withtheir transdifferetiation into myofiblast-like cells in culture. Bachem MG,Meyer D,Schafer W,et al. Journal of Hepatology . 1993
[4]  
The extracellular matrix in devel opment andin disease. Martin GRM,Kleinman HK. Seminars in Liver Disease . 1985
[5]  
Platelet - derived growth fator isolation by a large scaleprocedure and analysis of subunit composition. Hedlin CH. Biochemistry . 1981