丹皮酚的药理作用研究进展

被引：117

作者：

杨正生 ^{[1
,2
]}

彭振辉 ^{[1
]}

姚青海 ^{[3
]}

李扬 ^{[4
]}

机构：

[1] 西安交通大学第二附属医院皮肤科

[2] 秦皇岛市第一医院皮肤科

[3] 天津市胸科医院心内科

[4] 秦皇岛市第一医院科教科

来源：

中国药物与临床 | 2011年 / 11卷 / 05期

关键词：

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

<正>丹皮酚(Paeonol,Pae)又称牡丹酚,分离自中药牡丹、芍药的干燥根皮和徐长卿的根或全草,是一种具有广泛生物活性的物质。其化学名称为2-羟基-4-甲氧基苯乙酮,分子式为C9H10O3,相对分子质量为166.18。丹皮酚药理活性广泛,且具有半衰期短、不良反应少等优势,具有广泛的应用前景。本文对其药理学最新进展作一综述。

引用

页码：545 / 547

页数：3

共 15 条

[1]

Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-α and IL-1β release and augmentation of IL-10 production [J].

Cao, Wenjuan ;

Zhang, Wei ;

Liu, Jingjing ;

Wang, Yuan ;

Peng, Xuemei ;

Lu, Daxiang ;

Qi, Renbin ;

Wang, Yanping ;

Wang, Huadong .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2011, 11 (02) :172-178

[2]

Vascular dilation by paeonol — A mechanism study.[J].Ya-juan Li;Jun-Xiang Bao;Jin-wen Xu;Ferid Murad;Ka Bian.Vascular Pharmacology.2010, 3

[3]

Paeonol Attenuates High-Fat-Diet-Induced Atherosclerosis in Rabbits by Anti-Inflammatory Activity [J].

Li, Houkai ;

Dai, Min ;

Jia, Wei .

PLANTA MEDICA, 2009, 75 (01) :7-11

[4]

Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-α production.[J].Guo-Ping Sun;Hua Wang;Shu-Ping Xu;Yu-Xian Shen;Qiang Wu;Zhen-Dong Chen;Wei Wei.European Journal of Pharmacology.2008, 2

[5]

A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages [J].

Huang, H. ;

Chang, E. J. ;

Lee, Y. ;

Kim, J. S. ;

Kang, S. S. ;

Kim, H. H. .

INFLAMMATION RESEARCH, 2008, 57 (04) :189-198

[6]

Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells [J].

Zhang Chunhu ;

Hu Suiyu ;

Cao Meiqun ;

Xiao Guilin ;

Li Yunhui .

ANTI-CANCER DRUGS, 2008, 19 (04) :401-409

[7]

Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats [J].

Nizamutdinova, Irina Tsoy ;

Jin, Yong Chun ;

Kim, Ju Sun ;

Yean, Min Hye ;

Kang, Sam Sik ;

Kim, Yeong Shik ;

Lee, Jae Heun ;

Seo, Han Geuk ;

Kim, Hye Jung ;

Chang, Ki Churl .

PLANTA MEDICA, 2008, 74 (01) :14-18

[8]

Pharmacological investigations of the anti-diabetic effect of Cortex Moutan and its active component paeonol [J].

Lau, C. H. ;

Chan, C. M. ;

Chan, Y. W. ;

Lau, K. M. ;

Lau, T. W. ;

Lam, F. C. ;

Law, W. T. ;

Che, C. T. ;

Leung, P. C. ;

Fung, K. P. ;

Ho, Y. Y. ;

Lau, C. B. S. .

PHYTOMEDICINE, 2007, 14 (11) :778-784

[9]

Inhibition effects of Moutan Cortex Radicis on secretion of eotaxin in A549 human epithelial cells and eosinophil migration [J].

Kim, Jinju ;

Lee, Heekyung ;

Lee, Youngseop ;

Oh, Bang-Gul ;

Cho, Chongwoon ;

Kimb, Yangseok ;

Shinbe, Minkyu ;

Hong, Moochang ;

Jung, Sung-Ki ;

Bae, Hyunsu .

JOURNAL OF ETHNOPHARMACOLOGY, 2007, 114 (02) :186-193

[10]

The effects of paeonol on the electrophysiological properties of cardiac ventricular myocytes.[J].Yu-ling Ma;Susan Bates;Alison M. Gurney.European Journal of Pharmacology.2006, 2

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