ABC转运蛋白结构与转运机制的研究进展

被引：93

作者：

刘艳青

赵永芳

机构：

[1] 中国科学院生物物理研究所

来源：

生命科学 | 2017年 / 29卷 / 03期

关键词：

ABC转运蛋白; ATP水解; 转运机制;

D O I：

10.13376/j.cbls/2017031

中图分类号：

Q51 [蛋白质];

学科分类号：

070307 [化学生物学];

摘要：

腺苷三磷酸结合盒转运蛋白(ATP-binding cassette transporter,ABC转运蛋白)是一类跨膜蛋白,其主要功能是利用ATP水解产生的能量将底物进行逆浓度梯度运输。这类跨膜转运蛋白具有保守的功能结构域和多样化的生物学功能,广泛分布于原核和真核生物中。近几年的研究结果表明,人类多种疾病,如免疫缺陷、癌症等,都与ABC转运蛋白病变相关,因此这类转运蛋白结构及转运机制的研究受到广泛关注。现对近几年ABC转运蛋白结构及其转运机制的研究进展进行讨论。

引用

页码：223 / 229

页数：7

共 20 条

[1]

ABC transporter research: going strong 40 years on.[J].Theodoulou Frederica L.;Kerr Ian D..Biochemical Society Transactions.2015, 5

[2]

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade.[J].Rishil J. Kathawala;Pranav Gupta;Charles R. Ashby;Zhe-Sheng Chen.Drug Resistance Updates.2015,

[3]

Diversity in ABC transporters: Type I, II and III importers [J].

Rice, Austin J. ;

Park, Aekyung ;

Pinkett, Heather W. .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2014, 49 (05) :426-437

[4]

Analyzing conformational dynamics of single P-glycoprotein transporters by Förster resonance energy transfer using hidden Markov models.[J].Nawid Zarrabi;Stefan Ernst;Brandy Verhalen;Stephan Wilkens;Michael Börsch.Methods.2014, 2

[5]

Conformational changes of the bacterial type I ATP-binding cassette importer HisQMP2 at distinct steps of the catalytic cycle [J].

Heuveling, Johanna ;

Frochaux, Violette ;

Ziomkowska, Joanna ;

Wawrzinek, Robert ;

Wessig, Pablo ;

Herrmann, Andreas ;

Schneider, Erwin .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2014, 1838 (01) :106-116

[6]

Molecular mechanism of the Escherichia coli maltose transporter [J].

Chen, Jue .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2013, 23 (04) :492-498

[7]

Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA [J].

Tirado-Lee, Leidamarie ;

Lee, Allen ;

Rees, Douglas C. ;

Pinkett, Heather W. .

STRUCTURE, 2011, 19 (11) :1701-1710

[8]

Variation and evolution of the ABC transporter genes ABCB1; ABCC1; ABCG2; ABCG5 and ABCG8 : implication for pharmacogenetics and disease.[J].Latoya Silverton;Michael Dean;Karobi Moitra.Drug Metabolism and Drug Interactions.2011, 4

[9]

Phenotype Prediction of Non-Synonymous Single-Nucleotide Polymorphisms in Human ATP-Binding Cassette Transporter Genes [J].