氟伐他汀对自发性高血压大鼠阻力血管结构和功能的影响(英文)

被引：3

作者：

林志鸿

谢良地

吴可贵

王华军

许昌声

机构：

[1] 福建省高血压研究所,福建医科大学附属第一医院福州中国

来源：

Acta Pharmacologica Sinica | 1999年 / 09期

关键词：

氟伐他汀; 羟甲基戊二酰基辅酶A还原酶抑制剂; 近交系SHR大鼠; 胸主动脉; 肠系膜动脉; 血管舒张; 血管收缩; 高血压;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的:探讨氟伐他汀（HMG-CoA还原酶抑制剂）对自发性高血压大鼠阻力血管结构和功能的影响。方法:8周龄雄性SHR大鼠,氟伐他汀20mg·kg-1·d-1灌胃治疗。计算血管壁腔比作为阻力血管结构变化指标;应用离体主动脉和肠系膜动脉环对硝普钠和去甲肾上腺素反应的敏感性,观察治疗后血管的功能变化。结果:8周后,治疗组血管的壁腔比低于对照的SHR（0.44±0.09 vs 0.79±0.09,P<0.05）;氟伐他汀能增加SHR主动脉对硝普钠舒张的敏感性,EC50[（4.9 vs 190）pmol·L（-1）P<0.05];减弱主动脉和肠系膜动脉对去甲肾上腺素收缩的敏感性,EC50[主动脉:（0.20 vs 0.02）nmol·L-1,P<0.05;肠系膜动脉:（1.46 vs 0.72）nmol·L-1,P<0.05]。结论:短期氟伐他汀治疗,改善SHR大鼠阻力血管的舒缩功能,同时也抑制了SHR大鼠在血压发展过程中伴随的血管壁肥厚现象。

引用

页码：89 / 94

页数：6

共 15 条

[1]

Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Mulvany MJ,Halpern W. Circulation Research . 1977

[2]

Extrinsic mechanism of vascular growth. Folkow B. Journal of Clinical Hypertension . 1987

[3]

Inhibitory effects of fluvastatin, a new HMGCoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol-fed rabbits. Mitani H,Bandoh T,Ishikawa J,Kimura M,Totsuka T,Hayashi S. British Journal of Pharmacology . 1996

[4]

Inhibitory effect of fluvastatin at doses insufficient to lower serum lipids on the catheter-induced thickening of intima in rabbit femoral artery. Bandoh T,Mitani H,Niihashi M,Kusumi Y,Ishikawa J,Kimura M,et al. European Journal of Pharmacology . 1996

[5]

Effect of fluvastatin on growth of porcine and human vascular smooth muscle cells in vitro. Rogler G,Lacker KJ,Schmitz G. The American Journal of Cardiology . 1995

[6]

Involvement of rho P21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. Hirata K,Kikuchi A,Sasaki T,Kuroda S,Kaibuchi K,Matsuura Y,et al. Journal of Biological Chemistry . 1992

[7]

Is endothelial dysfunction reversible. Schmieder RE,Schobel HP. The American Journal of Cardiology . 1995

[8]

Cardiovascular structural adaption: its role in the initiation and maintenance of primary hypertension. Folkow B. Clinical Science and Molecular Medicine . 1987

[9]

Lovastatin prevents development of hypertension in spontaneously hypertensive rats. Jiang J,Roman RJ. Journal of Hypertension . 1997

[10]

Atherosclerosis[P]. DONG CHUNMING;GOLDSCHMIDT PASCAL J.中国专利:US2008095751A1,2008-04-24

← 1 2 →