桔梗皂苷对高脂大鼠血清指标的调节

被引:16
作者
吴敬涛 [1 ,2 ]
王建军 [2 ]
汤卫东 [2 ]
安利国 [1 ]
机构
[1] 不详
[2] 山东师范大学生命科学学院
[3] 不详
[4] 济南大学旅游学院
[5] 不详
关键词
桔梗皂甙; 血清指标; TG; TC; LDL-C; HDL-C; ApoAI; ApoB;
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
摘要
为研究桔梗皂甙对高脂大鼠血清指标的调节作用,将桔梗粉末以10倍量蒸馏水,浸泡2 h,超声振动处理30 min,滤除药渣,得提取液。同法再次提取一次,合并提取液,减压蒸干,以甲醇溶解,乙醚沉淀,得到皂甙。Wistar大鼠以高脂饲料饲喂,建立高血脂大鼠模型,分组灌胃生理盐水、阳性药物和桔梗皂甙溶液。尾静脉取血测定血清甘油三酯(TG)水平、总胆固醇(TC)水平、低密度脂蛋白胆固醇(LDL-C)水平、高密度脂蛋白胆固醇(HDL-C)水平、载脂蛋白AI(ApoAI)水平和载脂蛋白B(ApoB)水平等指标。结果表明:该法制备桔梗皂甙的方法简便、快速,得率高。桔梗皂甙对血清指标的调节作用显著,提示桔梗皂甙具有降血脂作用,是改善心血管生理功能的良好天然产物来源。
引用
收藏
页码:68 / 70
页数:3
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