桔梗皂苷对高脂大鼠血清指标的调节

被引：16

作者：

吴敬涛 ^{[1
,2
]}

王建军 ^{[2
]}

汤卫东 ^{[2
]}

安利国 ^{[1
]}

机构：

[1] 不详

[2] 山东师范大学生命科学学院

[3] 不详

[4] 济南大学旅游学院

[5] 不详

来源：

济南大学学报(自然科学版) | 2010年 / 01期

关键词：

桔梗皂甙; 血清指标; TG; TC; LDL-C; HDL-C; ApoAI; ApoB;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

为研究桔梗皂甙对高脂大鼠血清指标的调节作用,将桔梗粉末以10倍量蒸馏水,浸泡2 h,超声振动处理30 min,滤除药渣,得提取液。同法再次提取一次,合并提取液,减压蒸干,以甲醇溶解,乙醚沉淀,得到皂甙。Wistar大鼠以高脂饲料饲喂,建立高血脂大鼠模型,分组灌胃生理盐水、阳性药物和桔梗皂甙溶液。尾静脉取血测定血清甘油三酯(TG)水平、总胆固醇(TC)水平、低密度脂蛋白胆固醇(LDL-C)水平、高密度脂蛋白胆固醇(HDL-C)水平、载脂蛋白AI(ApoAI)水平和载脂蛋白B(ApoB)水平等指标。结果表明:该法制备桔梗皂甙的方法简便、快速,得率高。桔梗皂甙对血清指标的调节作用显著,提示桔梗皂甙具有降血脂作用,是改善心血管生理功能的良好天然产物来源。

引用

页码：68 / 70

页数：3

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