粘着斑激酶

被引：3

作者：

倪俊

陈玉林

机构：

[1] 第二军医大学长海医院烧伤中心!上海

来源：

生理科学进展 | 1999年 / 04期

关键词：

粘着斑激酶; 整合素; 酪氨酸磷酸化;

D O I：

暂无

中图分类号：

Q55 [酶];

学科分类号：

071010 ; 081704 ;

摘要：

粘着斑激酶（ｆｏｃａｌａｄｈｅｓｉｏｎｋｉｎａｓｅ，ＦＡＫ）是蛋白酪氨酸激酶，属于非受体蛋白酪氨酸激酶，分布在细胞粘着斑部位。ＦＡＫ位于神经肽、整合素和癌基因作用的聚合点，可发生酪氨酸磷酸化。它参与调节细胞发育、生长、存活、凋亡、粘附、骨架重组、转化、扩散和迁延等过程。

引用

页码：367 / 369

页数：3

共 9 条

[1]

Furuta Y,Ilic D,Kanazawa S,et al.Mesodermaldefect in late phase of gastrulation by a targetedm utation of focal adhesion kinase, Fak. Oncegene . 1995

[2]

Zachary I,Rozengur E.Focal adhesion kinase(p125 Fak) :a point of convergence in the action ofneuropeptides, intergrins and oncogenes. Cell . 1992

[3]

Yamada KM,Geiger B.Molecular interactions incell adhesion com plexes. Current Opinion in Cell Biology . 1997

[4]

Schlaeepfer DD,Hunter T.Focal adhesion kinaseoverexpression enhances rasdependent integrin signaling to ERK2/ mitogenactivated protein kinasethrough interaction with and activation of cSrc. Journal of Biological Chemistry . 1997

[5]

MiyamotoS,Akiyama SK,Yamada K.Synergisticroles forreceptor occupancy and aggregation inintegrin transmembrane function. Science . 1995

[6]

Iwaki K,Ohashi K,Ikeda M,et al.Decrease inthe amount of focal adhesion kinase (p125 FAK) ininterlukin1 betastimulated hu man u mbilical veinendothelial cells by binding of hu man monocytic celllines. Journal of Biological Chemistry . 1997

[7]

Hungerford JE,Com pton MT,Matter ML,et al.Inhibition of pp125 FAKin cultured fibroblasts resultsin apoptosis. JCell Biol . 1996

[8]

Zheng C,Xing Z,Bian ZC,et al.Differential regulation of Pyk2 and focal adhesion kinase(FAK).The Cterminal do main of FAK confers response tocell adhesion. Journal of Biological Chemistry . 1998

[9]

Llic D,Damsky Ch,Yamamto T.Focal adhesionkinase: at the crossroads of signal transduction. JCell Sci . 1997

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