血小板活化特异性标志物PAC-1和CD62p与急性脑梗死病情严重程度的相关性

被引：14

作者：

张炘 ^{[1
]}

段传志 ^{[1
]}

李铁林 ^{[1
]}

龙霄翱

何旭英 ^{[1
]}

谭峰 ^{[2
]}

方美凤 ^{[2
]}

黄彪 ^{[2
]}

机构：

[1] 南方医科大学珠江医院神经外科广东神经外科研究所

[2] 广州中医药大学附属佛山中医院神经内科

来源：

中国神经精神疾病杂志 | 2011年 / 37卷 / 11期

关键词：

PAC-1; CD62p; ACI; 病情; 相关性;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨急性脑梗死(acute cerebral infarction,ACI)患者血小板膜糖蛋白(glycoproteinⅡb/Ⅲa,GPⅡb/Ⅲa)纤维蛋白原受体PAC-1和P选择素(P-Selectin,CD62p)与ACI患者病情严重程度的相关性。方法采用流式细胞仪技术分别检测58例ACI患者急性期(<7 d)外周血PAC-1和CD62p含量,同时采用Barthel指数和NIHSS量表评分法对ACI患者进行神经功能学评分,并选取20名健康人作为对照组进行参考值测定。结果与对照组(0.22±0.13;4.21±1.11)相比,ACI患者PAC-1含量(0.92±0.40)和CD62p含量(7.07±3.07)在急性期(<7 d)显著升高(P<0.05;P<0.05),且与ACI患者病情严重程度成正相关(P<0.05;P<0.01)。结论 PAC-1和CD62p与ACI患者病情严重程度呈正相关。早期检测PAC-1和CD62p水平对于预防ACI发生、评估病情轻重以及判断预后有着重要的意义。

引用

页码：698 / 701+694 +694

页数：5

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