To study the mental health of patients with nasopharyngeal carcinoma (NPC). Methods: SCL-90, SAS and SDS were applied to inpatients with NPC (60 case), inpatients with hepatitis (30 case) and healthy people (30 cases). Results: ① Compared with healthy people, patients with NPC showed significantly higher scores in all but social sensitivity, hostility, paranoia and psychiatric domains in SCL-90. The total score, postive record number, depression and anxiety scores in NPC patients were significantly higher than those in patients with hepatitis. ②The prevalence of depression and anxiety in NPC group were significantly higher than those in the two control groups. Conclusion: Patients with NPC had more psychiatric symptoms and poorer mental health. Psychological intervention was important in the treatment of NPC.