阿朴菲类生物碱抗癌活性研究进展

被引：27

作者：

刘言娟 ^{[1
,2
]}

柳军玺 ^{[1
]}

邸多隆 ^{[1
]}

机构：

[1] 中国科学院兰州化学物理研究所,中科院西北特色植物资源化学重点实验室,甘肃省天然药物重点实验室

[2] 中国科学院研究生院

来源：

中草药 | 2012年 / 43卷 / 04期

关键词：

生物碱; 阿朴菲类生物碱; 天然产物; 抗癌活性; 细胞毒活性;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

阿朴菲类生物碱是一类重要的天然产物,其抗癌活性是近几年药学研究的热点。查阅国内外相关文献,总结阿朴菲类生物碱抗癌活性的基本构效关系、抗癌活性及其作用机制。1,2-亚甲二氧基及N-甲基取代对于该类化合物的细胞毒活性较关键,C-7的氧化和脱氢有助于提高该类化合物的抗癌活性,C-6a的手性及其他位置取代基对于抗癌活性的贡献目前尚未明确。阿朴菲类生物碱主要通过诱导细胞凋亡、抑制细胞增殖以及抑制DNA拓扑异构酶机制发挥抗癌作用。

引用

页码：806 / 814

页数：9

共 23 条

[1]

Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: An SAR study [J].

Ponnala, Shashikanth ;

Chaudhary, Sandeep ;

Gonzalez-Sarrias, Antonio ;

Seeram, Navindra P. ;

Harding, Wayne W. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (15) :4462-4464

[2]

Cytotoxic Aporphine Alkaloids from Ocotea acutifolia [J].

Garcez, Fernanda R. ;

da Silva, Ana Francisca G. ;

Garcez, Walmir S. ;

Linck, Gabriela ;

Matos, Maria de Fatima C. ;

Santos, Evelyn C. S. ;

Queiroz, Lyara M. M. .

PLANTA MEDICA, 2011, 77 (04) :383-387

[3]

Chemical investigation of drug-like compounds from the Australian tree, Neolitsea dealbata [J].

Tran, Trong D. ;

Pham, Ngoc B. ;

Fechner, Gregory ;

Quinn, Ronald J. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (19) :5859-5863

[4]

The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea [J].

da Silva, D. B. ;

Tulli, E. C. O. ;

Militao, G. C. G. ;

Costa-Lotufo, L. V. ;

Pessoa, C. ;

de Moraes, M. O. ;

Albuquerque, S. ;

de Siqueira, J. M. .

PHYTOMEDICINE, 2009, 16 (11) :1059-1063

[5]

Nature: a vital source of leads for anticancer drug development [J].

Cragg, G. M. ;

Newman, D. J. .

PHYTOCHEMISTRY REVIEWS, 2009, 8 (02) :313-331

[6]

Boldine: a potential new antiproliferative drug against glioma cell lines [J].

Gerhardt, Danieli ;

Horn, Ana Paula ;

Gaelzer, Mariana Maier ;

Frozza, Rudimar Luiz ;

Delgado-Canedo, Andres ;

Pelegrini, Alessandra Luiza ;

Henriques, Amelia T. ;

Lenz, Guido ;

Salbego, Christianne .

INVESTIGATIONAL NEW DRUGS, 2009, 27 (06) :517-525

[7]

Cytotoxic and Antitumor Potentialities of Aporphinoid Alkaloids.[J].C. Stevigny;C. Bailly;J. Quetin-Leclercq.Current Medicinal Chemistry-Anti-Cancer Agents.2005, 2

[8]

Alkaloids from Cassytha filiformis and related aporphines:: Antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases [J].

Hoet, S ;

Stévigny, C ;

Block, S ;

Opperdoes, F ;

Colson, P ;

Baldeyrou, B ;

Lansiaux, A ;

Bailly, C ;

Quetin-Leclercq, J .

PLANTA MEDICA, 2004, 70 (05) :407-413

[9]

Aporphine Alkaloids from Guatteria spp. with Leishmanicidal Activity.[J].Hector Montenegro;Marcelino Gutiérrez;Luz Romero;Eduardo Ortega-Barría;Todd Capson;Luis Rios.Planta Med.2003, 07

[10]

Cytotoxic aporphine alkaloids from Cassytha filiformis [J].

Stévigny, C ;

Block, S ;

De Pauw-Gillet, MC ;

de Hoffmann, E ;

Llabrès, G ;

Adjakidjé, V ;

Quetin-Leclercq, J .

PLANTA MEDICA, 2002, 68 (11) :1042-1044

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